Research Article

The Efficacy of Combined Therapy of Regorafenib with Detoxicating and Stasis Softening Chinese Herbal Spleen Tonics in Mid-/Late-Stage Hepatocellular Carcinoma

Table 3

PFS, TTP, and OS of REG and REG-DSS group patients.

GroupTTP (95% CI)PFS (95% CI)OS (95% CI)

REG6.8 (3.5–9.7)6.8 (3.5–9.7)17.2 (11.5–22.8)
Treatment ≥4.2 m7.1 (5.8–8.6)7.1 (5.8–8.6)
Treatment <4.2 m3.7 (2.5–4.8)3.7 (2.5–4.8)

REG-DSS7.3 (4.2–9.9)7.3 (4.2–9.9)18.2 (12.6–23.4)
Treatment ≥4.2 m7.9 (6.8–8.9)7.9 (6.8–8.9)
Treatment <4.2 m4.6 (3.2–6.2)4.6 (3.2–6.2)

Overall7.1 (3.9–9.8)7.1 (3.9–9.8)17.6 (11.5–22.8)
Treatment ≥4.2 m7.6 (6.6–8.5)7.6 (6.6–8.5)
Treatment <4.2 m4.3 (2.0–6.5)4.3 (2.0–6.5)

DSS-spleen tonics had synergistic antitumor efficacy with Regorafenib in HCCLM3 cell line.