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Contrast Agents, Radiotracers, Radiation Dose, and Safety

Call for Papers

Contrast agents are crucial elements of radiological imaging studies. In the recent years, questions about the safety profiles of these agents are frequently raised. Regarding the iodinated contrast agents, the major problems are their nephrotoxicity and adverse effects including fatal anaphylactic reactions. Regarding “Gd-containing MR contrast agents,” NSF and the accumulation of gadolinium in the basal ganglia are the two major issues. Use of both iodinated and Gd-containing contrast agents in the pregnant or lactating women and in the pediatric patients is a further challenge that needs to be addressed and overcome. The same problems are also relevant for radiotracers that are being used in nuclear medicine.

Thus, the scope of this proposed special issue will be the safety issues regarding the iodinated and Gd-containing contrast agents and radiotracers including the frequency of their short-term and long-term side-effects, the ways to avoid them, nephrotoxicity risk related to the iodinated contrast agents, NSF (nephrogenic systemic fibrosis), accumulation of gadolinium in the brain, use of contrast agents in pediatric patients and pregnancy and contrast agents, adverse effects of radiotracers such as F18-FDG and Ga-68, and finally radiation dose issues related to both CT imaging and nuclear medicine studies.

Potential topics include but are not limited to the following:

  • Nephrotoxicity related to use of iodinated contrast agents and how to manage it
  • Adverse reactions of iodinated contrast agents and how to avoid them
  • The differences of iodinated contrast agents regarding their side effects and nephrotoxicity
  • Nephrogenic systemic fibrosis: has it really disappeared
  • Gadolinium accumulation in the brain: a monster or a pet
  • Iodinated contrast agents and pregnancy: do we need to avoid them completely
  • Gadolinium and pregnancy
  • Lactation and contrast agents
  • How safe are radiotracers
  • PET-tracers and safety issues
  • How to optimize radiation dose regarding PET and SPECT imaging?
  • Ga-67 imaging and radiation dose issues
  • Pharmacokinetics and pharmacodynamics of iodinated contrast agents
  • Pharmacokinetics and pharmacodynamics of gadolinium-containing agents
  • Magnesium as a MR contrast agent
  • CT imaging of pediatric patients: how to manage the radiation dose effectively
  • Contrast enhanced mammography and issues related to radiation dose

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 23 March 2018
Publication DateAugust 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

Lead Guest Editor

  • Pablo R. Ros, University Hospitals Health System, Cleveland, USA

Guest Editors