Contrast Media & Molecular Imaging

Liver Imaging and Hepatobiliary Contrast Media


Status
Published

1Hôpitaux Universitaires de Genève, Geneva, Switzerland

2Austrian Institute of Technology, Vienna, Austria

3Laboratoire des Biomarqueurs en Imagerie, Clichy, France


Liver Imaging and Hepatobiliary Contrast Media

Description

Understanding hepatocyte concentrations of compounds is a new translational topic. In the past, understanding compound distribution in the liver has been primarily made through the decrease of plasma concentrations. When conducting pharmacokinetic studies, it was assumed that liver concentrations approximate plasma concentrations. With the emerging knowledge of hepatocyte membrane transporters, it is clear that this assumption is no longer valid. Thus, depending on the relative influx and efflux clearances of compounds, hepatocyte concentrations can exceed, equal, or be lower than plasma concentrations. Disconnection between hepatocyte and plasma concentrations is even more unpredictable when expression and function of membrane transporters are altered during liver diseases.

With advances in liver imaging (PET, SPECT, and MRI), quantification of liver concentrations is now possible following the administration of hepatobiliary compounds. Using pharmacokinetic modeling, liver imaging can also predict the influx and efflux functions across hepatocyte transporters.

This special issue focuses on the understanding of liver imaging with hepatobiliary contrast media. We encourage the submission of original articles on basic, translational, and clinical studies, as well as reviews that describe topics linked to liver imaging with hepatobiliary contrast media.

Potential topics include but are not limited to the following:

  • MRI, PET, and SPECT with hepatobiliary contrast agents in experimental and clinical studies
  • Liver pharmacokinetics to understand the transport of contrast media across hepatocyte membranes and transporters
  • Liver imaging to detect drug toxicity
  • Hepatobiliary concentrations of compounds assessed with cell or organ imaging

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 2487405
  • - Editorial

Liver Imaging and Hepatobiliary Contrast Media

Catherine M. Pastor | Oliver Langer | Bernard E. Van Beers
  • Special Issue
  • - Volume 2018
  • - Article ID 3064751
  • - Research Article

Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters

Andrea Testa | Sergio Dall’Angelo | ... | Matteo Zanda
  • Special Issue
  • - Volume 2018
  • - Article ID 8489709
  • - Clinical Study

Noninvasive Monitoring of Liver Disease Regression after Hepatitis C Eradication Using Gadoxetic Acid-Enhanced MRI

Lukas Haider | Mattias Mandorfer | ... | Ahmed Ba-Ssalamah
  • Special Issue
  • - Volume 2018
  • - Article ID 3839108
  • - Review Article

Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA

Catherine M. Pastor
  • Special Issue
  • - Volume 2018
  • - Article ID 5849047
  • - Research Article

Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice

Marco F. Taddio | Linjing Mu | ... | Stefanie D. Krämer
  • Special Issue
  • - Volume 2018
  • - Article ID 7310146
  • - Research Article

Positron Emission Tomography Imaging Reveals an Importance of Saturable Liver Uptake Transport for the Pharmacokinetics of Metoclopramide

Fabien Caillé | Sébastien Goutal | ... | Nicolas Tournier
  • Special Issue
  • - Volume 2018
  • - Article ID 6345412
  • - Research Article

Evaluating Hepatobiliary Transport with 18F-Labeled Bile Acids: The Effect of Radiolabel Position and Bile Acid Structure on Radiosynthesis and In Vitro and In Vivo Performance

Stef De Lombaerde | Ken Kersemans | ... | Filip De Vos
  • Special Issue
  • - Volume 2018
  • - Article ID 6321316
  • - Research Article

Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model

Myung-Won You | Hyoung Jung Kim | ... | Young-Joo Lee
Contrast Media & Molecular Imaging
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Acceptance rate58%
Submission to final decision65 days
Acceptance to publication40 days
CiteScore3.200
Impact Factor1.984
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