Computational and Mathematical Methods in Medicine

Computational and Mathematical Methods in Medicine / 1999 / Article

Open Access

Volume 1 |Article ID 901905 | 11 pages | https://doi.org/10.1080/01445349908833025

The Diameter Distribution of the Stem Villi Arteries Does Not Discriminate between Normal and Intra Uterine Growth Restricted Placentas

Received13 Apr 1998
Revised15 Oct 1998
Accepted08 Dec 1998

Abstract

The distribution of the stem villi arteries and arterioles diameter was evaluated on histological sections from 6 normal (control) and 8 Intrauterine Growth Restricted (IUGR) placentas. No significant difference between the diameter distributions was found. This result can be due either to a similar pattern in vascularization or to the inadequacy of the diameter distribution in showing existing differences. Further investigation is needed to make a distinction between these two hypotheses. A multiparametric model is proposed, which predicts the diameter distribution that is expected when a few parameters (describing the vessel geometry and the tree branching structure) are varied in their normal range. The diameter distribution is shown to slightly change or not to change at all when important parameters, such as the vessel asymmetry, are changed. We conclude that the diameter distribution is insensitive to variation in certain placental structural parameters. A reliable analysis of the stem villi vasculature in normal and TUGR placentas cannot be based on the comparison of the respective diameter distributions alone.

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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