Computational and Mathematical Methods in Medicine

Computational and Mathematical Methods in Medicine / 2003 / Article

Open Access

Volume 5 |Article ID 168014 |

Hugo A. van den Berg, Carmen Molina-París, "Thymic Presentation of Autoantigens and the Efficiency of Negative Selection", Computational and Mathematical Methods in Medicine, vol. 5, Article ID 168014, 22 pages, 2003.

Thymic Presentation of Autoantigens and the Efficiency of Negative Selection

Received11 Mar 2003
Accepted21 Jun 2003


Antigen recognition by the adaptive cellular immune system is based on a diverse repertoire of antigen receptors. Since this repertoire is formed by genetic recombination, a number of receptors are autoreactive by chance, giving rise to the threat of autoimmune disease. Potentially autoreactive T lymphocytes (T cells) are rendered ineffective by various tolerance mechanisms. One of these mechanisms is negative selection, the deletion from the repertoire of immature autoreactive T cells in the thymus. The present paper shows how to assess the contribution made by negative selection relative to other tolerisation mechanisms by deducing the impact of negative selection on the T cell repertoire from the statistics of autoantigen presentation in the thymus.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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