Original Article | Open Access
V. Brown, K. A. J. White, "The HPV Vaccination Strategy: Could Male Vaccination Have a Significant Impact?", Computational and Mathematical Methods in Medicine, vol. 11, Article ID 395631, 15 pages, 2010. https://doi.org/10.1080/17486700903486613
The HPV Vaccination Strategy: Could Male Vaccination Have a Significant Impact?
We investigate the potential success of the human papilloma virus (HPV) vaccine, taking into consideration possible waning immunity and the influence of behavioural parameters. We use a compartmental, population-level ordinary differential equation (ODE) model. We find the effective reproductive value for HPV, , which measures the threshold for infection outbreak in a population that is not entirely susceptible, together with infection prevalence. We study the effects of different parameters on both of these quantities. Results show that waning immunity plays a large part in allowing infection to persist. The proportion of the population not sexually active when vaccination occurs affects , as does the rate at which individuals become sexually active. In several cases, infection persists as a result of an infection reservoir in the male cohort. To explore this further, we introduce male vaccination and find the conditions for which vaccination of males could be considered appropriate.
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