Quantitative Measurements in 3-Dimensional Datasets of Mouse Lymph Nodes Resolve Organ-Wide Functional Dependencies

Figure 4

Histograms of the distances from the DCs to closest HEV, for the same PLNs as Figures 3(a) and 3(c) wt-PLN, (b) and (d) plt-PLN. Mean distance for DCs in wt-PLN is much larger than for the plt/plt mutant, reflecting the high density of the HEV in the periphery. The red vertical line marks the mean distance, the dashed lines mark the standard deviation. (e) Schematic 2D depiction of the HEV (red) and DCs (cyan). The minimum distances between the CoMs of the DCs and the HEV are indicated by white arrows and dashed circles.