Simulation of Arrhythmogenic Effect of Rogue RyRs in Failing Heart by Using a Coupled Model
Figure 2
Simulation results of membrane potential () (a), cytoplasmic Ca2+ concentration (b), SR luminal Ca2+ concentration ([Ca2+]SR) (c), and (d) during a single twitch. The red curve represents the time course of those parameters in failing myocytes, while the blue curve is the time course of those parameters in control myocytes.