Research Article

Simulation of Arrhythmogenic Effect of Rogue RyRs in Failing Heart by Using a Coupled Model

Table 1

Parameters in nonfailing versus failing myocyte models.

ParametersDefinitionNonfailingFailing

Maximal SR Ca2+ pumping rate0.006375 mM/ms0.0035 mM/ms
Maximal conductance0.392 nS/pF0.196 nS/pF
Maximal conductance5.405 nS/pF4.324 nS/pF
Maximal conductance0.294 nS/pF0.185 nS/pF
Maximal conductance14.838 nS/pF8.902 nS/pF
Maximal 2.724 pA/pF1.57 pA/pF
Maximal conductance0.000592 nS/pF0.0009045 nS/pF
Maximal 1000 pA/pF1650 pA/pF
Ca2+ sensitivity parameters of RyR clusters or rogue RyR when they take the same value15  M7.5  M
luminal Ca2+ sensitivity parameter of Ca2+ release events3.25 mM2.5 mM