Research Article
Simulation of Arrhythmogenic Effect of Rogue RyRs in Failing Heart by Using a Coupled Model
Table 1
Parameters in nonfailing versus failing myocyte models.
| Parameters | Definition | Nonfailing | Failing |
| | Maximal SR Ca2+ pumping rate | 0.006375 mM/ms | 0.0035 mM/ms | | Maximal conductance | 0.392 nS/pF | 0.196 nS/pF | | Maximal conductance | 5.405 nS/pF | 4.324 nS/pF | | Maximal conductance | 0.294 nS/pF | 0.185 nS/pF | | Maximal conductance | 14.838 nS/pF | 8.902 nS/pF | | Maximal | 2.724 pA/pF | 1.57 pA/pF | | Maximal conductance | 0.000592 nS/pF | 0.0009045 nS/pF | | Maximal | 1000 pA/pF | 1650 pA/pF | | Ca2+ sensitivity parameters of RyR clusters or rogue RyR when they take the same value | 15 M | 7.5 M | | luminal Ca2+ sensitivity parameter of Ca2+ release events | 3.25 mM | 2.5 mM |
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