Influence of Expert-Dependent Variability over the Performance of Noninvasive Fibrosis Assessment in Patients with Chronic Hepatitis C by Means of Texture Analysis

Algorithm 1

ROI establishment.

Input: patients—a set with patients and ultrasound images

Output: DS—a list with 25 sets 𝐷𝑆_𝑖𝑗 with regions of interest

For 𝑖=1 to 5

   𝐷_𝑖 = Perform a randomization on patients

   For 𝑗=1 to 5

      Sequentially present to expert 𝑗 dataset 𝐷_𝑖

      𝐷𝑆_𝑖𝑗 = established ROIs