Predictive Models for Maximum Recommended Therapeutic Dose of Antiretroviral Drugs

Table 2

The results of the multiple linear regression analysis for antiretroviral drugs versus MRTD. In the training, dataset only two of the six molecular descriptors showed a statistically significant correlation with therapeutic dose, that is, P[BD] (𝑃 = 0.0349) and ASol (𝑃 = 0.0140). A multiple regression model equation coefficients are listed with there standard errors, coefficient of determination (𝑅²=0.5970), multiple correlation coefficient (MCC = 0.7727) and residual standard deviation (RSD = 33.89).

Multiple linear regression	𝑛=23	𝑅^2=0.5970	RSD = 33.89	MCC = 0.7727
independent variables	Coefficient	SE	𝑃-value	𝑅𝐳
Constant	−34.3303
AlogP	−12.1995	6.6976	0.0873	−0.221
ASol	2.1239	0.7697	0.0140	0.476
logBioHL	15.9000	8.0377	0.0654	−0.071
MW	0.2159	0.1015	0.0494	−0.116
OxidHL	5.6589	2.8478	0.0643	0.448
P[BD]	46.5133	20.1746	0.0349	0.427
ANOVA	F-ratio = 3.9507	𝑃=0.013