Predictive Models for Maximum Recommended Therapeutic Dose of Antiretroviral Drugs

Table 4

Test dataset Goodness of fit comparisons. Clinical MRTD values from 8 ARVs were using as and external test dataset the validate model predictability. Model performance is characterized here in terms of root means squared error (RMSE), Kendall’s correlation coefficient (tau), and Type II error probability (𝑃-value).

Drug	MRTD	MLR	SE	TNN	SE
Abacavir	10.00	−10.6738	427.4060	6.4861	12.3474
Emtricitabine	4.00	−23.9239	779.7441	3.3678	0.3996
Raltegravir	30.07	0.0628	900.4320	19.7700	106.0900
Nevirapine	3.00	−54.1862	3270.2614	−16.5700	382.9849
Efavirenz	10.10	−10.2863	415.6012	−5.7782	252.1172
Fosamprenavir	46.70	44.0515	7.0145	50.7500	16.4025
Atazanavir	5.35	11.4360	37.0393	29.8700	601.2304
Lopiravir	53.33	42.6361	114.3594	64.5900	126.7876
Mean	20.32	−0.1105	RMSE = 27.27	19.06	RMSE = 13.67
Kendall’s tau		0.714		0.643
𝑃-value		0.019		0.035