A General Latent Class Model for Performance Evaluation of Diagnostic Tests in the Absence of a Gold Standard: An Application to Chagas Disease

Table 1

Settings used for the simulation of artificial data.

	Covariate (𝑊)
	𝑊=0		𝑊=1
Stratum	V		V
Parameter	1	2	1	2
𝜉𝑣|𝑊	0.10	0.60	0.30	0.90
Se1|𝑊	0.50		0.60
Se2|𝑊	0.75		0.80
Se3|𝑊	0.90		0.95
Sp1|𝑊	0.60		0.50
Sp2|𝑊	0.80		0.75
Sp3|𝑊	0.95		0.90

𝜉_𝑣|𝑊: prevalence rates in vth stratum to covariate 𝑊; Se_𝑘|𝑊 and Sp_𝑘|𝑊: sensitivity and specificity of kth test in vth stratum to covariate 𝑊.