Spongiosa Primary Development: A Biochemical Hypothesis by Turing Patterns Formations

Figure 1

Control system of the molecular process. VEGF: vascular endothelial growth factor; MMP13: matrix metalloproteinase 13, the figure shows the ratio of the molecular signals produced by the hypertrophy of chondrocytes. The solid lines mean activation, dotted lines inhibition, continuous curved lines self-activation, and dotted curved lines self-inhibition.