Membrane Protein Stability Analyses by Means of Protein Energy Profiles in Case of Nephrogenic Diabetes Insipidus

Figure 2

The quality index plot of the aquaporin-2 structure model produced by VADAR. The structure model of aquaporin-2, which is necessary for protein-energy-profile-based analysis, was reevaluated using the structure analysis tool VADAR [29]. One evaluation criterion given by VADAR is the quality index per residue. It indicates weak spots in the model, for example, side chain misfolding, stereochemical overlaps, insufficient atom packing, and so on. Here, the plot points to a high structure model quality.