Table 3: Equivalent invariant residues between the HCV template and the Dengue virus polymerase model in the vicinity of the ssRNA fragment or the UTP substrate.

SubstratessRNAUTP
Interacting invariant RdRp residuesHCV RdRp structureDengue virus ModelMotifHCV RdRp structureDengue virus ModelMotif

D220D312IVD318D441VI
D318D441VID319D442VI
D319D442VID220D312IV
N291N388VK155K247II
T287T384V
R158R250II
E143E327I
S282S379V
K141K235I
R168R260II
R394R515Conserved