Superficial Collagen Fibril Modulus and Pericellular Fixed Charge Density Modulate Chondrocyte Volumetric Behaviour in Early Osteoarthritis
Figure 6
Cell volume (black), average pericellular fibril strain (red), and average pericellular osmotic pressure (blue) after the free swelling step in the contralateral (CNTRL) and anterior cruciate ligament transected (ACLT) models as a function of the pericellular fixed charge density. Osmotic pressure behavior is the same in both models. Note the change in the fibril strain and cell volume when the fixed charge density of the PCM is nearly equal to that of the chondrocyte ( mEq/mL).
