The Number of Candidate Variants in Exome Sequencing for Mendelian Disease under No Genetic Heterogeneity

Table 1

Expected numbers of SNVs for the parents genotypes and probabilities for sibs genotypes.

Genotype configuration of the parents	Expected number of SNVs	Genotype; of sib	Probability for genotype
𝑅𝑅×𝑅𝐴	𝐸𝐾𝑅𝑅×𝑅𝐴: 𝜃	𝑅𝑅	1/2
		𝑅𝐴	1/2
𝑅𝑅×𝐴𝐴	𝐸𝐾𝑅𝑅×𝐴𝐴: 𝜃/6	𝑅𝐴	1
𝑅𝐴×𝑅𝐴	𝐸𝐾𝑅𝐴×𝑅𝐴: 𝜃/3	𝑅𝑅	1/4
		𝑅𝐴	1/2
		𝐴𝐴	1/4
𝑅𝐴×𝐴𝐴	𝐸𝐾𝑅𝐴×𝐴𝐴: 𝜃/3	𝑅𝐴	1/2
		𝐴𝐴	1/2
𝐴𝐴×𝐴𝐴	𝐸𝐾𝐴𝐴×𝐴𝐴: 𝜃/4	𝐴𝐴	1