Spatiotemporal Dynamic Simulation of Acute Perfusion/Diffusion Ischemic Stroke Lesions Evolution: A Pilot Study Derived from Longitudinal MR Patient Data

Table 2

Insights into final T2 outcome Columns 1 and 3 show the mean value of dice index over time for the 8 patients between the estimated evolving DWI/MTT lesion boundaries from acute to subacute stages and the final T2 lesion boundary. Columns 2 and 4 show the time corresponding to the maximum value that the dice index reached, where the final T2 lesion is spatially closest to the estimated DWI/MTT evolution. Columns 5 and 7 display the mean value of the symmetric distance over time computed in mm (the spatial discrepancy) between the evolving DWI/MTT boundaries and the final T2 boundary. Columns 6 and 8 depict the time of the “appearance” (in hours) of the T2 within the DWI and MTT evolution scenarios corresponding to the minimum of the symmetric distance that varied with time—for each patient.

Mean𝑡diceMTT(𝑡)	𝑡^diceMTT,T2	Mean𝑡diceDWI(𝑡)	𝑡^diceDWI,T2	Mean𝑡𝑑symMTT(𝑡)	𝑡^𝑑symMTT,T2	Mean𝑡𝑑symDWI(𝑡)	𝑡^𝑑symDWI,T2
0.574	30	0.682	144	6.109	42	4.719	144
0.598	9	0.817	129	7.086	9	3.828	132
0.052	216	0.029	216	33.23	216	24.285	216
0.003	3	0.227	216	28.593	3	16.681	216
0.007	123	0.0008	123	23.886	123	26.128	120
0.364	273	0.556	273	9.295	270	6.151	99
0.42	54	0.61	6	10.45	87	6.160	6
0.681	75	0.77	198	7.925	69	4.713	237