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Computational and Mathematical Methods in Medicine
Volume 2013, Article ID 297463, 6 pages
Research Article

Optimization of Contrast-to-Tissue Ratio by Adaptation of Transmitted Ternary Signal in Ultrasound Pulse Inversion Imaging

1IUT Ville d’Avray, Université Paris Ouest Nanterre La Défense, 92 410 Ville d’Avray, France
2UMR-S930, Université François-Rabelais de Tours, 37032 Tours, France
3U 930, Inserm, 37032 Tours, France

Received 20 December 2012; Accepted 18 February 2013

Academic Editor: Kumar Durai

Copyright © 2013 Sébastien Ménigot and Jean-Marc Girault. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ultrasound contrast imaging has provided more accurate medical diagnoses thanks to the development of innovating modalities like the pulse inversion imaging. However, this latter modality that improves the contrast-to-tissue ratio (CTR) is not optimal, since the frequency is manually chosen jointly with the probe. However, an optimal choice of this command is possible, but it requires precise information about the transducer and the medium which can be experimentally difficult to obtain, even inaccessible. It turns out that the optimization can become more complex by taking into account the kind of generators, since the generators of electrical signals in a conventional ultrasound scanner can be unipolar, bipolar, or tripolar. Our aim was to seek the ternary command which maximized the CTR. By combining a genetic algorithm and a closed loop, the system automatically proposed the optimal ternary command. In simulation, the gain compared with the usual ternary signal could reach about 3.9 dB. Another interesting finding was that, in contrast to what is generally accepted, the optimal command was not a fixed-frequency signal but had harmonic components.