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Computational and Mathematical Methods in Medicine
Volume 2013 (2013), Article ID 413783, 8 pages
http://dx.doi.org/10.1155/2013/413783
Research Article

Integrative Genomics with Mediation Analysis in a Survival Context

1Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
2Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
3Division of Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden

Received 28 May 2013; Accepted 23 September 2013

Academic Editor: Lev Klebanov

Copyright © 2013 Szilárd Nemes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

This Supplementary Materials contains the theoretical background for the Delta-method and a brief derivation of the variance estimators. Moreover, we provide the variance estimators for the extended casual path when the hypothesized effect of DNA copy number aberrations on survival is mediated by the mRNA-protein pathway. The Supplementary Materials concludes with a short R script that implements the advocated method.

  1. Supplementary Material