Research Article

Integrative Genomics with Mediation Analysis in a Survival Context

Table 1

Results of simulation of the characteristics of the 95% CI for the mediation effect. The lower and upper errors denote the number of times when these intervals fell below or above the true population value.

CoverageLower errorUpper errorWidth

Delta method0.9770.0030.0204.288
Product normal0.9510.0150.0344.514
Boot
 Normal0.9950.0010.0046.153
 Base0.9960.0010.0036.286
 Percentile0.9440.0290.0276.286
 BCa0.9520.0240.0246.224

Delta method0.9710.0060.0232.587
Product normal0.9540.0180.0282.663
Boot
 Normal0.9840.0040.0123.036
 Base0.9870.0030.0103.118
 Percentile0.9420.0310.0273.118
 BCa0.9540.0220.0243.099

Delta method0.9690.0090.0222.008
Product normal0.9610.0150.0242.047
Boot
 Normal0.9800.0070.0132.215
 Base0.9850.0040.0112.268
 Percentile0.9500.0270.0232.268
 BCa0.9630.0200.0172.253

Delta method0.9600.0150.0251.672
Product normal0.9470.0250.0281.696
Boot
 Normal0.9650.0120.0231.801
 Base0.9770.0070.0161.839
 Percentile0.9430.0270.0301.839
 BCa0.9470.0250.0281.831