Application of Design of Experiment for Floating Drug Delivery of Tapentadol Hydrochloride

Table 4

Evaluation results of formulations F1–F9.

Formulation no.	% Drug release within 8 hrs.	% Drug content	Swelling index	Buoyancy lag time (sec.)	Hardness; (kg/cm^2)
F1	95.8	98.60	286.7	69	7.8
F2	98.01	99.24	291.1	48	8.1
F3	96.48	97.89	302.7	75	8.6
F4	98.04	99.09	277.9	62	8.0
F5	102.05	101.80	292.2	58	6.9
F6	97.57	98.93	305.4	91	7.3
F7	95.96	100.56	290.4	53	8.6
F8	100.14	102.37	283.7	58	8.1
F9	97.22	101.46	307.9	85	8.8