Modeling of Non-Small Cell Lung Cancer Volume Changes during CT-Based Image Guided Radiotherapy: Patterns Observed and Clinical Implications
Figure 1
Block diagram of the proliferation model. A fraction of newborn cells directly enters the cycling stage, while the others become quiescent (Q or ). Quiescent cells either die (with a rate ) or reenter into the cycling stage (with a “recycling” rate ). The parameter is zero or very low (say no more than 0.01, meaning 1% of quiescent cells become cycling per day—otherwise these cells were not “quiescent”). Cycling cells traverse the cell cycle (G1 + S + G2 M) in an average time , after which they divide generating two newborn cells. The parameters and are dependent on the input values of , , , and . Modeling of the proliferation is based on the general mathematical theory of proliferating cell populations (see Ubezio and Cameron [16] and the references therein).
