TY - JOUR
A2 - Palmans, Hugo
AU - Thrapsanioti, Zoi
AU - Karanasiou, Irene
AU - Platoni, Kalliopi
AU - Efstathopoulos, Efstathios P.
AU - Matsopoulos, George
AU - Dilvoi, Maria
AU - Patatoukas, George
AU - Chaldeopoulos, Demetrios
AU - Kelekis, Nikolaos
AU - Kouloulias, Vassilis
PY - 2013
DA - 2013/11/19
TI - Transformation of Physical DVHs to Radiobiologically Equivalent Ones in Hypofractionated Radiotherapy Analyzing Dosimetric and Clinical Parameters: A Practical Approach for Routine Clinical Practice in Radiation Oncology
SP - 713420
VL - 2013
AB - Purpose. The purpose of this study was to transform DVHs from physical to radiobiological ones as well as to evaluate their reliability by correlations of dosimetric and clinical parameters for 50 patients with prostate cancer and 50 patients with breast cancer, who were submitted to Hypofractionated Radiotherapy. Methods and Materials. To achieve this transformation, we used both the linear-quadratic model (LQ model) and the Niemierko model. The outcome of radiobiological DVHs was correlated with acute toxicity score according to EORTC/RTOG criteria. Results. Concerning the prostate radiotherapy, there was a significant correlation between RTOG acute rectal toxicity and D50 (P<0.001) and V60 (P=0.001) dosimetric parameters, calculated for α/β=10 Gy. Moreover, concerning the breast radiotherapy there was a significant correlation between RTOG skin toxicity and V≥60 dosimetric parameter, calculated for both α/β=2.3 Gy (P<0.001) and α/β=10 Gy (P<0.001). The new tool seems reliable and user-friendly. Conclusions. Our proposed model seems user-friendly. Its reliability in terms of agreement with the presented acute radiation induced toxicity was satisfactory. However, more patients are needed to extract safe conclusions.
SN - 1748-670X
UR - https://doi.org/10.1155/2013/713420
DO - 10.1155/2013/713420
JF - Computational and Mathematical Methods in Medicine
PB - Hindawi Publishing Corporation
KW -
ER -