TY - JOUR A2 - Palmans, Hugo AU - Thrapsanioti, Zoi AU - Karanasiou, Irene AU - Platoni, Kalliopi AU - Efstathopoulos, Efstathios P. AU - Matsopoulos, George AU - Dilvoi, Maria AU - Patatoukas, George AU - Chaldeopoulos, Demetrios AU - Kelekis, Nikolaos AU - Kouloulias, Vassilis PY - 2013 DA - 2013/11/19 TI - Transformation of Physical DVHs to Radiobiologically Equivalent Ones in Hypofractionated Radiotherapy Analyzing Dosimetric and Clinical Parameters: A Practical Approach for Routine Clinical Practice in Radiation Oncology SP - 713420 VL - 2013 AB - Purpose. The purpose of this study was to transform DVHs from physical to radiobiological ones as well as to evaluate their reliability by correlations of dosimetric and clinical parameters for 50 patients with prostate cancer and 50 patients with breast cancer, who were submitted to Hypofractionated Radiotherapy. Methods and Materials. To achieve this transformation, we used both the linear-quadratic model (LQ model) and the Niemierko model. The outcome of radiobiological DVHs was correlated with acute toxicity score according to EORTC/RTOG criteria. Results. Concerning the prostate radiotherapy, there was a significant correlation between RTOG acute rectal toxicity and D50 (P<0.001) and V60 (P=0.001) dosimetric parameters, calculated for α/β=10 Gy. Moreover, concerning the breast radiotherapy there was a significant correlation between RTOG skin toxicity and V60 dosimetric parameter, calculated for both α/β=2.3 Gy (P<0.001) and α/β=10 Gy (P<0.001). The new tool seems reliable and user-friendly. Conclusions. Our proposed model seems user-friendly. Its reliability in terms of agreement with the presented acute radiation induced toxicity was satisfactory. However, more patients are needed to extract safe conclusions. SN - 1748-670X UR - https://doi.org/10.1155/2013/713420 DO - 10.1155/2013/713420 JF - Computational and Mathematical Methods in Medicine PB - Hindawi Publishing Corporation KW - ER -