Optimisation of Ionic Models to Fit Tissue Action Potentials: Application to 3D Atrial Modelling
Figure 6
Optimised cSAN and pSAN models using a cSAN-pSAN 2D tissue axisymmetric disc model with = 800 μS·cm−1. (a) The optimised cSAN and pSAN AP waveforms () are overlaid on top of AP traces recorded experimentally () from cSAN, pSAN, and RA myocytes, respectively, from a rabbit sino-atrial tissue preparation. (b) Inward, outward, and leakage ionic currents reconstructed from the optimised cSAN, pSAN, and RA models, respectively. Note the different scales used for currents in cSAN, pSAN, and RA.
