Optimisation of Ionic Models to Fit Tissue Action Potentials: Application to 3D Atrial Modelling

Table 3

Optimised generic ionic model parameter values used in the 3D atrial models. Parameter values were obtained by optimising a cSAN-pSAN-RA and LA-PV 2D axisymmetric disc models.

Current	Parameter	cSAN	pSAN	RA	LA	PV
𝐼1	𝑔1 (µS·cm^−2)	20.75	40.61	332.25	295.3	3098.3
	𝐸rev,1 (mV)	−83.96	−97.57	−86.46	−93.4	−91.9
	𝑘𝛼𝑝1 (s^−1)	4775.9	3202.9	2008.02	4805.4	1415.6
	𝑠𝛼𝑝1 (mV^−1)	−3.56	−0.72	−0.158	−0.094	−0.087
	𝑘𝛽𝑝1 (s^−1)	16.02	50.02	75.02	0	4
	𝑠𝛽𝑝1 (mV^−1)	3.11	0	0	0.058	0.002
	𝐸50,𝑝1 (mV)	−60.71	−53.04	−63.97	−76.5	−70.4
	𝑘𝛼𝑞1 (s^−1)	14.22	142.89	198.22	327	18.4
	𝑠𝛼𝑞1 (mV^−1)	−5	−1.99	0	−0.054	−0.001
	𝑘𝛽𝑞1 (s^−1)	0.21	58.92	293.23	2041.5	1198.3
	𝑠𝛽𝑞1 (mV^−1)	0.16	0.76	0.17	0.06	0.2
	𝐸50,𝑞1 (mV)	−21.86	−97.73	−0.83	−79.9	−11.5
𝐼2	𝑔2 (µS·cm^−2)	6758.38	2856.22	6904.07	4479.9	16283.6
	𝐸rev,2 (mV)	16.19	8.12	40.01	43.5	40
	𝑘𝛼𝑝2 (s^−1)	4.37	123.81	562.54	2000	241.3
	𝑠𝛼𝑝2 (mV^−1)	−3.7	−4.19	−0.185	−0.198	−0.2
	𝑘𝛽𝑝2 (s^−1)	3347.16	2643.18	4999.1	1005.4	4770.6
	𝑠𝛽𝑝2 (mV^−1)	0.14	0.06	0.001542	0.058	0.001
	𝐸50,𝑝2 (mV)	−62.77	−67.13	−44.12	−42.2	−43.5
	𝑘𝛼𝑞2 (s^−1)	3.68	4.86	30.97	10	10
	𝑠𝛼𝑞2 (mV^−1)	3.32	1.62	0.123	0.199	0.122
	𝑘𝛽𝑞2 (s^−1)	35.32	28.56	44.85	43	27.7
	𝑠𝛽𝑞2 (mV^−1)	−4.99	−1.85	−0.18	−0.004	−0.159
	𝐸50,𝑞2 (mV)	−48.39	−69.48	−60.15	−63.3	−64.8
𝐼𝐿	𝑔𝐿 (µS·cm^−2)	2.93	16.047	13.5	10	11.5
	𝐸rev,𝐿 (mV)	5.07	−71.67	−57.5	−51.9	−60

𝐼₁: outward current, 𝐼₂: inward time-dependent current, 𝐼_𝐿: leakage current.