Epitope Mapping of Metuximab on CD147 Using Phage Display and Molecular Docking

Table 3

Epitope mapping solution no. 1 based on mimotope analysis.

Mimotope	Predicted epitopic residues
YPHFHKHTLRGH	L101, H102, G103, P104, R106, P132, P133, T135, T188, K191, G192
YPHFHKHSLRGQ	S78, Q81, Q100, L101, H102, G103, P104, R106, S128, S130, P132, P133, S189, S190, K191, G192, S193
DHKPFKPTHRTL	L101, H102, P104, R106, P132, P133, T135, T188, K191, D194
FHKPFKPTHRTL	L101, H102, P104, R106, P132, P133, T135, T188, K191
QSSCHKHSVRGR	V30, S78, Q81, Q100, H102, G103, R106, S128, S130, V131, S189, S190, K191, G192, S193
QSSFSNHSVRRR	V30, S78, Q81, Q100, H102, R106, S128, S130, V131, S189, S190, S193
Union	V30, S78, Q81, Q100, L101, H102, G103, P104, R106, S128, S130, V131, P132, P133, T135, T188, S189, S190, K191, G192, S193, D194; 22 residues in total.