Computational and Mathematical Methods in Medicine / 2013 / Article / Tab 1

Research Article

Understanding the Pathogenesis of Kawasaki Disease by Network and Pathway Analysis

Table 1

Candidate gene studies identified genes associated with KD.

SymbolRegionPhenotypeCountryReference

CD4020q12-q13.2KDTaiwan[20]
CALTaiwan[20]
CD20919p13KDTaiwan[21]
RETN19p13.2Incomplete KDChina[22]
KDUnited States[23]
CALJapan[24]
FCGR3B1q23IVIG nonresponseUnited States[23]
NOD17p15-p14KDJapan[25]
NLRP117p13.2KDJapan[25]
ITPKC19q13.1KDTaiwan; Japan; China[2628]
CALJapan[29]
IVIG nonresponseJapan[29]
TGFBR2 3p22KD European descent; Korea[30, 31]
CALEuropean descent; Korea[30, 31]
IVIG nonresponseEuropean descent [30]
aortic root dilatation, European descent[30]
ABO9q34.2CALJapan[32]
PELI12p13.3CALKorea[33]
SMAD315q22.33KD European descent; Taiwan [30, 34]
CALEuropean descent [30]
IVIG nonresponse European descent [30]
aortic root dilatationEuropean descent[30]
TGFB21q41KD European descent; Taiwan [30, 34]
CALEuropean descent [30]
IVIG nonresponseEuropean descent [30]
aortic root dilatation,European descent [30]
CASP34q34CALTaiwan; Japan[29, 35]
IVIG nonresponseJapan[29]
ANGPT18q23.1KDNetherlands [36]
VEGFA6p12KDNetherlands; Taiwan; The Netherlands. [3638]
CALJapan[39]
MICB6p21.3KD Taiwan[40]
CALTaiwan[40]
MICA6p21.33KDTaiwan[40]
CALTaiwan[41]
BAG66p21.3KD Taiwan[40, 42]
CAATaiwan[42]
MSH56p21.3KDTaiwan[40]
VWA76p21.33KDTaiwan[40]
FCGR2B1q23IVIG nonresponsePacific Northwest[43]
IL101q31-q32KDTaiwan[44, 45]
CALChina; Korea; Taiwan[18, 46, 47]
CCL517q11.2-q12CALIndia[48]
TNFRSF1A12p13.2KDChina[49]
CTLA42q33CAL (particularly in female patients)Taiwan[50]
MMP311q22.3CALKorea; US-UK, tested in Japan[51, 52]
MMP1211q22.3CALUS-UK, tested in Japan[52]
FGB 4q28CALChina[53]
CCL3L117q21.1KDUSA; Japan[54, 55]
IVIG nonresponseJapan[55]
CCR53p21.31KDUSA; The Netherlands (Dutch Caucasian); Korea[54, 56, 57]
CALJapan[55]
IVIG nonresponse Japan[55]
PRRC2A 6p21.3KD Taiwan[42]
CALTaiwan[42]
ABHD16A6p21.3KD Taiwan[42]
CALTaiwan[42]
ITPR36p21CALTaiwan[58]
COL11A26p21.3KD Taiwan[59]
CALTaiwan[59]
MBL2 10q11.2KDChina; Japan[60, 61]
CALThe Netherlands; The Netherlands[62, 63]
Arterial stiffnessChina[64]
MMP11 22q11.23KDKorea[65]
MIF22q11.23CALItaly[66]
IL1B 2q14IVIG nonresponseTaiwan[17]
BTNL26p21.3KD Taiwan[67]
CALTaiwan[67]
TPH212q21.1CALKorea[68]
PDCD12q37.3KDKorean[69]
IL1811q22.2-q22.3KDTaiwan[70, 71]
HLA-E6p21.3KD Taiwan[72]
CALTaiwan[72]
TIMP43p25CAL Korea[73]
HLA-G6p21.3KDKorea[74]
CRP1q21-q23KDChina [75]
Carotid stiffness and carotid intima-media thicknessChina [75]
TNF6p21.3KDChina [75]
CALwhite [76]
Intima-media thicknessChina [75]
IVIG nonresponse China [46]
MMP1311q22.3CALJapan [77]
HLA-B6p21.3KDKorea [78]
HLA-C6p21.3KDKorea [78]
CCR33p21.3KDNetherlands (Dutch Caucasian) [56]
CCR23p21.31KDNetherlands (Dutch Caucasian) [56]
TIMP217q25CALJapan [79]
ACE17q23.3KDTaiwan; Korea [80, 81]
Coronary artery stenosis Japan [82, 83]
Myocardial ischemiaJapan [82]
PLA2G76p21.2-p12IVIG nonresponseJapan [84]
IL1RN2q14.2KDTaiwan [85]
IL45q31.1KDUSA [86]
KDR4q11-q12CALJapan [39]
CD40LGXq26CAL: males affectedJapan[87]
AGTR13q24Coronary artery stenosis and myocardial ischemiaJapan[82]
CD145q31.1CALJapan[88]
SLC11A12q35KDJapan [89]
LTA 6p21.3KDwhite[76]
MTHFR1p36.3CALJapan[90]
HP 16q22.2late diagnosis of KD Taiwan[90]

KD: kawasakidisease;CAL: coronary artery lesions; CAA: coronary artery aneurysms.