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Computational and Mathematical Methods in Medicine
Volume 2014, Article ID 245610, 8 pages
http://dx.doi.org/10.1155/2014/245610
Research Article

Dynamics of Posttranslational Modifications of p53

1Institute of Systems Biology, Shanghai University, 99 Shangda Road, Shanghai 200444, China
2College of Fundamental Studies, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai 201620, China
3Guangxi Academy of Sciences, 98 Daling Road, Nanning, Guangxi 530007, China
4DreamSciTech, Apartment 207, Zhencaili 26, Zhujiang Road, Hexi District, Tianjin 300222, China

Received 19 February 2014; Accepted 6 April 2014; Published 12 May 2014

Academic Editor: Lei Chen

Copyright © 2014 Qing-Duan Fan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Geva-Zatorsky, N. Rosenfeld, S. Itzkovitz et al., “Oscillations and variability in the p53 system,” Molecular Systems Biology, vol. 2, no. 1, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Batchelor, C. S. Mock, I. Bhan, A. Loewer, and G. Lahav, “Recurrent initiation: a mechanismfor triggering p53 pulses in response to DNA damage,” Molecular Cell, vol. 30, no. 3, pp. 277–289, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Ma, J. Wagner, J. J. Rice, W. Hu, A. J. Levine, and G. A. Stolovitzky, “A plausible model for the digital response of p53 to DNA damage,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 40, pp. 14266–14271, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Charvet, M. Wissler, P. Brauns-Schubert et al., “Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53,” Molecular Cell, vol. 42, no. 5, pp. 584–596, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. H. C. Reinhardt and B. Schumacher, “The p53 network: cellular and systemic DNA damage responses in aging and cancer,” Trends in Genetics, vol. 28, no. 3, pp. 128–136, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Batchelor, A. Loewer, C. Mock, and G. Lahav, “Stimulus-dependent dynamics of p53 in single cells,” Molecular Systems Biology, vol. 7, article 488, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. S. L. Harris and A. J. Levine, “The p53 pathway: positive and negative feedback loops,” Oncogene, vol. 24, no. 17, pp. 2899–2908, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. X.-P. Zhang, F. Liu, and W. Wang, “Two-phase dynamics of p53 in the DNA damage response,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 22, pp. 8990–8995, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Dimitrio, J. Clairambault, and R. Natalini, “A spatial physiological model for p53 intracellular dynamics,” Journal of Theoretical Biology, vol. 316, pp. 9–24, 2013. View at Publisher · View at Google Scholar
  10. J. Eliaš, L. Dimitrio, J. Clairam-bault, and R. Natalini, “The p53 protein and its molecular network: modelling a missing link between DNA damage and cell fate,” Biochimica et Biophysica Acta, vol. 1844, no. 1, Part B, pp. 232–247, 2014. View at Publisher · View at Google Scholar
  11. J. E. Purvis, K. W. Karhohs, C. Mock et al., “p53 dynamics control cell fate,” Science, vol. 336, no. 6087, pp. 1440–1444, 2012. View at Publisher · View at Google Scholar
  12. T. Sun, W. Yang, J. Liu, and P. Shen, “Modeling the basal dynamics of P53 system,” PLoS ONE, vol. 6, no. 11, Article ID e27882, 2011. View at Publisher · View at Google Scholar
  13. B. Liu, S. Yan, and Q. Wang, “Intrinsic noise and Hill dynamics in the p53 system,” Journal of Theoretical Biology, vol. 269, no. 1, pp. 104–108, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Puszyński, B. Hat, and T. Lipniacki, “Oscillations and bistability in the stochastic model of p53 regulation,” Journal of Theoretical Biology, vol. 254, no. 2, pp. 452–465, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. Y.-C. Hung and C.-K. Hu, “Constructive role of noise in p53 regulatory network,” Computer Physics Communications, vol. 182, no. 1, pp. 249–250, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. G. S. Ivanov, T. Ivanova, J. Kurash et al., “Methylation-acetylation interplay activates p53 in response to DNA damage,” Molecular and Cellular Biology, vol. 27, no. 19, pp. 6756–6769, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Kuroda, A. Murayama, N. Katagiri et al., “RNA content in the nucleolus alters p53 acetylation via MYBBP1A,” EMBO Journal, vol. 30, no. 6, pp. 1054–1066, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Loewer, E. Batchelor, G. Gaglia, and G. Lahav, “Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells,” Cell, vol. 142, no. 1, pp. 89–100, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Tang, W. Zhao, Y. Chen, Y. Zhao, and W. Gu, “Acetylation is indispensable for p53 activation,” Cell, vol. 133, no. 4, pp. 612–626, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. S. M. Sykes, T. J. Stanek, A. Frank, M. E. Murphy, and S. B. McMahon, “Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53,” Journal of Biological Chemistry, vol. 284, no. 30, pp. 20197–20205, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. H. M. Collins, M. K. Abdelghany, M. Messmer et al., “Differential effects of garcinol and curcumin on histone and p53 modifications in tumor cells,” BMC Cancer, vol. 13, no. 1, article 37, 2013. View at Publisher · View at Google Scholar
  22. X. Chen, J. Chen, S. Gan et al., “DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control,” BMC Biology, vol. 11, article 73, 2013. View at Publisher · View at Google Scholar
  23. J. K. Sax, P. Fei, M. E. Murphy, E. Bernhard, S. J. Korsmeyer, and W. S. El-Deiry, “BID regulation by p53 contributes to chemosensitivity,” Nature Cell Biology, vol. 4, no. 11, pp. 842–849, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Liu, L. Bardwell, and Q. Nie, “A combination of multisite phosphorylation and substrate sequestration produces switchlike responses,” Biophysical Journal, vol. 98, no. 8, pp. 1396–1407, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. J.-P. Kruse and W. Gu, “Modes of p53 regulation,” Cell, vol. 137, no. 4, pp. 609–622, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. D. W. Meek and C. W. Anderson, “Posttranslational modification of p53: cooperative integrators of function,” Cold Spring Harbor Perspectives in Biology, vol. 1, no. 6, Article ID a000950, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Dai, Y. Tang, S. Y. Jung, J. Qin, S. A. Aaronson, and W. Gu, “Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 47, pp. 18937–18942, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. X.-P. Zhang, F. Liu, Z. Cheng, and W. Wang, “Cell fate decision mediated by p53 pulses,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 30, pp. 12245–12250, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. Jiang, R. Kamath, S. Jin, M. Balasubramani, T. K. Pandita, and B. Rajasekaran, “Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl,” Molecular Cancer, vol. 10, article 88, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. C. D. Knights, J. Catania, S. Di Giovanni et al., “Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate,” Journal of Cell Biology, vol. 173, no. 4, pp. 533–544, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. Z. Feng, C. Zhang, R. Wu, and W. Hu, “Tumor suppressor p53 meets microRNAs,” Journal of Molecular Cell Biology, vol. 3, no. 1, pp. 44–50, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Hermeking, “MicroRNAs in the p53 network: micromanagement of tumour suppression,” Nature Reviews Cancer, vol. 12, no. 9, pp. 613–626, 2012. View at Publisher · View at Google Scholar