Designing Lead Optimisation of MMP-12 Inhibitors

Figure 4

Estimated density function of response variable of the whole experimental space (2500 compounds). In yellow the response values of the initial population composed of 𝑚₁=100 compounds. The next populations, composed of 𝑚_𝑘=10 compounds, 𝑘=2,3, are represented by orange and green points.