Research Article

Modeling and Visualizing Cell Type Switching

Figure 3

The genetic regulatory network used in this work for modeling myeloid differentiation. Nodes are eleven transcription factors that control cell lineage and edges are regulatory interactions between the transcription factors. An arrow signifies activation and a closed line signifies inhibition. The Boolean regulatory control functions are not shown. This network was discovered using a new search algorithm (paper in preparation) that uncovers networks that can produce a particular set of cell types, but it does not necessarily find the actual biological network.
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