Research Article
Structure-Functional Prediction and Analysis of Cancer Mutation Effects in Protein Kinases
Table 1
Structurally conserved cancer mutation hotspots in protein kinase genes.
| Reference (EGFR) | Segment | Number of mutations | Number of drivers | Mutations | Activation status |
| L718 | P-loop | 4 | 4 | ABL L248V | Activating | BRAF I462S | EGFR L718P | JAK3 L527P |
| G721 | P-loop | 5 | 4 | EGFRG721 | Activating | BRAF G464A/E/R/V | caMLCK G601E | MLK2 G107E | NDR2 G99A | AurC G52E |
| T790 | Hinge | 6 | 5 | EGFR T790M | Activating | ABL T315I/N | FGFR4 V550M | KIT T670E | PDGFRa T674I | NEK11 T108M |
| G796 | Hinge | 5 | 5 | EGFR G796S | Activating | ABL G321E | ErbB2 G804S | IRR G1065E | LKB1 G135R |
| D855 | Activation | 5 | 5 | BRAF D594E | Inactivating | DAPK3 D161N | HCK D378G | LKB1 D194V | LYN D385Y |
| G857 | Activation | 6 | 5 | BRAF G596R | Inactivating | EPHA3 G766E | FYN G410R | JNK1 G171S | MAST2 G655A | CDK11 G175S |
| L858 | Activation | 3 | 3 | EGFR L858R | Activating | BRAF L596V | ErbB2 L866R |
| L861 | Activation | 8 | 8 | EGFR L861Q/R | Activating | ABL L387M | BRAFV600D/E/G/K/L/M | ErbB2 L869Q | FLT3 D835E/F/H/N/V/Y | KIT D816E/F/V/H/I/N/V | MET D1246H/N/V | PDGFRa D842I/V/Y |
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