Computational and Mathematical Methods in Medicine

Volume 2014 (2014), Article ID 810680, 10 pages

http://dx.doi.org/10.1155/2014/810680

## Improving the Performance of the Prony Method Using a Wavelet Domain Filter for MRI Denoising

Escuela de Matemáticas, Facultad de Ciencias, Universidad Nacional de Colombia, Medellín, Colombia

Received 11 February 2014; Accepted 18 March 2014; Published 14 April 2014

Academic Editor: Fenglin Liu

Copyright © 2014 Rodney Jaramillo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

#### Abstract

The Prony methods are used for exponential fitting. We use a variant of the Prony method for abnormal brain tissue detection in sequences of weighted magnetic resonance images. Here, MR images are considered to be affected only by Rician noise, and a new wavelet domain bilateral filtering process is implemented to reduce the noise in the images. This filter is a modification of Kazubek’s algorithm and we use synthetic images to show the ability of the new procedure to suppress noise and compare its performance with respect to the original filter, using quantitative and qualitative criteria. The tissue classification process is illustrated using a real sequence of MR images, and the filter is applied to each image before using the variant of the Prony method.

#### 1. Introduction

The main goal of this paper is to detect abnormal tissues in weighted magnetic resonance image sequences. The identification of the distribution of relaxation times in weighted magnetic resonance brain images has been used to classify tissues and as a tool for the segmentation of tumors [1–3]. This is possible because the tissue corresponding to a given pixel in a sequence of weighted MRI images is characterized by a relaxation rate and therefore allows for differentiation of the tissues that conform to the region determined by a set of pixels. In this paper, we assume that the intensity at a pixel, in a sequence of weighted MRI brain images, can be approximated by where is the echo time interval. Here, represents the intensity of gray in the pixel, is the number of images in the sequence, and is the number of tissues considered in the pixel, . The exponents are called the nonlinear parameters and correspond to the relaxation rates associated with the different tissues present in the images, and the coefficients are called the linear parameters and are related to the background noise of the image and the proportions of each one of the tissues in the pixel, respectively. The background noise is the noise which comes from all possible sources, some of which are unknown, and usually corresponds to patient movement and the image acquisition process. Martín-Landrove et al. [3, 4] proposed the model and used a variant of Prony’s method to find the linear and nonlinear parameters. We have used two methods to compute the parameters in the exponential model (1): the variant of the Prony method already mentioned [3–6] and the variable projection method of Golub and Pereyra [7–9]. Prony-type methods are widely used for estimating a signal frequency component; a discussion of such methods can be found in [10–13]. On the other hand, the variable projection method has been used in many applications in fields like electrical engineering, medical image processing, chemical sciences, environmental sciences, magnetic resonance applications, and so forth. A comprehensive bibliographic reference can be found in [8], (144 items).

In [5] Paluszny et al., comparing the solution obtained by the variant of the Prony method and the solution given by the variable projection method, it was noted that both methods successfully converge in the case of low level noisy data, and none produces a satisfactory solution for high noise levels; the variable projection method proved to be more robust in the presence of higher noise levels but required ten times more computational time to get results comparable to those of the variant of the Prony method.

The exponential fit given by (1) is an ill-conditioned problem, and this means that relatively small changes in the data may result in large variations in the linear and nonlinear parameters; therefore, a filter is required to modify the data before using any of the considered methods. In particular, [6] provides an analysis of the sources of instability for the variant of the Prony method.

In the literature, there are a number of different filters to enhance MRI. We chose to modify the filter designed by Kazubek [14], to get a wavelet domain filter for removing noise on each image, before applying the Prony method, and trying to keep the computation time low.

#### 2. Wavelet Domain Filters for MRI Denoising

##### 2.1. The Two-Dimensional Wavelet Transform

Let us consider an image , and let be the gray intensity corresponding to the pixel given by coordinates . The discrete wavelet transform (DWT) is a decomposition of in two functions: where is a representation of in terms of shifted and dilated versions of a low-pass scaling function and is a representation of in terms of shifted and dilated versions of a prototype bandpass wavelet function . The coefficients which determine the components and are called scaling coefficients and wavelet coefficients, respectively. Once the functions and have been chosen, the components and are uniquely determined by the coefficients; therefore, it is said that the discrete wavelet transform consists of the two sets of coefficients. The scaling coefficients allow for a low resolution reconstruction of the image and the wavelet coefficients deal with the reconstruction of the details.

There is a large amount of bibliographic information about the theoretical as well as computational aspects of the DWT; we will give, here, a brief description to point out the relevant issues regarding the design of a filter, in the wavelet domain, for MR images.

##### 2.2. Wavelet Domain Filters for MRI

When we consider a noisy image and its DWT, it is supposed that the noise in the image is determined by the noise associated with the scaling and wavelet coefficients. A wavelet domain filter corresponds to two procedures, one for the noise reduction in the scaling coefficients and the other for dealing with the noise associated with the wavelet coefficients. The filtered image is the result of applying the inverse wavelet transform to the modified coefficients. The differences between various proposals for wavelet domain filters lie in the algorithms to be applied to each one of the two sets of coefficients; see, for example, [14–22].

Although the noise in MRI comes from various sources, we consider that the perturbation in magnitude follows a Rice distribution, [15, 23]. Kazubek considers that most of the energy used in the image generation corresponds to the scaling coefficients and hence these contribute the most to the perturbation of the image in the presence of noise; therefore, Kazubek proposes to apply a filter to reduce the noise in the scaling coefficients under the hypothesis that the noise is Rician.

According to some authors, numerical experiments show that noise in the wavelet coefficients can be approximated by a Gaussian distribution; for this reason we made a satisfactory noise reduction in these coefficients using a Wiener filter (consult [14, 15, 21]) in addition to the Kazubek filter in the scaling coefficients.

The arithmetic mean of a random variable which follows a Rician distribution is a biased estimator of the value without noise. The next section shows a brief description of the Rician noise and a formula for reducing the bias between the value without noise and the arithmetic mean. We will use this formula later in the filter, on the scaling coefficients.

#### 3. Removing the Bias from Rice Distributed Data

In a magnetic resonance image, the gray intensity corresponding to a given pixel is the magnitude of a complex valued function whose real and imaginary components are distributed as Gaussians with the same standard deviation. The different approaches for MRI noise removal can be divided into three classes; some methods act on the real and imaginary components, most of the methods deal with the square of the magnitude, and a third kind of methods acts on the magnitude of the complex image. We are interested in the latter class of methods because our data are in magnitude.

In [14], Kazubek implements a wavelet domain filter which acts on the magnitude of the image and whose relevant issues are the use of the Haar system of orthogonal functions in the wavelet transform and a formula to apply on the scaling coefficients that is used to suppress the bias discussed in Section 2.

Next, we present an analysis of Kazubek's formula for bias removal and propose a modification of his algorithm by applying the bilateral filter to the scaling coefficients [24].

Let and be the mean values of two random variables and , respectively, which are the real and imaginary components of a complex image. If and are distributed as Gaussians with standard deviation , then the probability density function for the magnitude, , is a Rice distribution given by where is the modified Bessel function of the first kind and zeroth order and is the underlying noise-free signal amplitude. Let be the mean value of ; then, where and is the modified Bessel function of the first kind and first order [15].

Let ; we can get a numerical approximation of the inverse for .

We have that implies ; then, the inverse function corresponds to a signal whose noise measurement runs from to 34 decibels, (dB).

Bessel functions and satisfy ; then, and using the power series expansion of functions , , and , we get (Details of the proof can be found in the Appendix.) Therefore, is a monotonically increasing function in the interval and .

Using polynomial approximations of the functions for (consult Abramowitz and Stegun [25]), we get where and . Then, for large , behaves as the function

On the other hand, we have and a straightforward computation shows that

This function is a particular case of function with and .

The idea to get a numerical approximation of consists in considering a function such that function and its derivative satisfy similar asymptotic features of and , respectively. Let and let ; if we consider , then

is a monotonically increasing function in the interval with . Function takes positive values and is a monotonically decreasing function in the same interval. Then, there is a unique positive root, , of and if , then

It follows that is the domain of

To get the parameters , , , and , we perform a least square fit to the discretized curve for and , . This problem was solved numerically using the MATLAB function* lsqcurvefit*. With MATLAB R2008a and taking the initial values , we get the optimal solution: , , , and . Figure 1(a) shows the function as a numerical approximation of and Figure 1(b) shows the quality if the solution given by the MATLAB function* lsqcurvefit*. In MRI, as in acoustic, electricity, and telecommunications, the signal to noise ratio (SNR) is frequently used to measure, in decibels, the noise impact on a signal. Let and be two gray level images, a reference image and a noisy image , of size . The SNR is computed as

Nowak [15] suggests that a SNR greater than 10 dB corresponds to a noisy image, whose Rice distribution can be approximated by a Gaussian distribution. We will consider a method to suppress the bias in our MR images using the inverse function discussed in this section when SNR is less than 34 dB and a simple wavelet domain filter for the other cases.

#### 4. Implementing a New Wavelet Domain Bilateral Filter for MRI

##### 4.1. Formula for the Scaling Coefficients

The component in (2) is a linear combination of functions that belong to a specific family of orthogonal functions; each scaling coefficient depends on three parameters: , the level of decomposition in the discrete wavelet transform, and the pair which characterizes the support of the corresponding orthogonal function. Let be the function in (2); if we apply the discrete wavelet transform using the Haar system of orthogonal functions, then the scaling coefficients are given by

Details can be found in [26].

##### 4.2. Wiener Filter for the Wavelet Coefficients

As the scaling coefficients, the wavelet coefficients depend on three parameters , . For simplicity, let us write and suppose that the noise in the wavelet coefficients may be approximated by a Gaussian distribution [14]. Then, we attenuate the contribution of this coefficient by

According to Nowak, we assume that the noise wavelet coefficient is an unbiased estimator of the value of the wavelet coefficient in the noise-free case and denote its mean by . The filter weight is chosen by minimizing . In fact, if is the variance of the wavelet coefficient , then therefore is defined by

Let be an estimate of ; then,

Usually the parameter is approximated by , where is a new parameter to be chosen for each image and is as defined in Section 2. In previous works [15, 18, 21], the value has proven to be convenient. Hence, the filter weight in (20) is defined by

##### 4.3. Bilateral Filtering

The bilateral filter is a nonlinear filter for images, proposed by Tomasi and Manduchi [24], whereby contours are successfully recovered from noisy images. Let be a pixel in image ; the bilateral filter takes a sum with weights on the pixels in a local neighborhood of , . These weights depend on the spatial distance and the intensity in each pixel in the neighborhood. The response of the bilateral filter in the pixel is given by where

The performance of the bilateral filter depends on the choice of , and the size of the neighborhood . Let be a pixel located close to an edge which separates two regions of the image. When the pixel is in the same region as , is close to one; on the other hand, when is in the other region, then is close to zero if the intensities and differ greatly and then the filter tends to preserve the pixel intensity due to the effect of the components.

In our proposal the bilateral filter is applied to the two-dimensional array consisting of the scaling coefficients of the wavelet transform . We follow Anand and Sahambi [20] and choose the neighborhood to be a matrix centered at and the parameters and , where is the standard deviation given in Section 3.

##### 4.4. Algorithm for MRI Denoising

(1)Compute an approximation of the variance, , choosing a rectangular neighborhood , in the background of the image [15]: (2)Perform a level wavelet decomposition using the Haar system of orthogonal functions.(3)Perform a bias correction of the level 3 scale coefficients using the inverse function considered in Section 3. From (19) we see that is an approximation to the expected value given in (4) so that is an approximation of the value defined in Section 2. Using (4) and (17), we get Now we compute the new scaling coefficients by (4)Apply the bilateral filter to the two-dimensional array , given by the new scaling coefficients: .(5)Obtain a provisional denoised image, , computing the inverse wavelet transform using the new scaling coefficients and the unchanged wavelet coefficients.(6)Perform a level wavelet decomposition of using the Daubechie system with four vanishing moments.(7)Perform a correction of the wavelet coefficients given in (6) using (20) and (24).(8)Get a denoised image by computing the inverse wavelet transform on the set of coefficients given by the scaling coefficients in (6) and the new wavelet coefficients in (7).

#### 5. Validation of the MRI Filter Applied to Simulated Images

We compare the performances of the modified and the original Kazubek's filter using a synthetic image generated with MATLAB, see Figure 2, and introduce the noisy images by adding Rician noise to the synthetic image. The Rician noise was generated as where is the true signal and and are random numbers from a Gaussian distribution with mean zero and standard deviation ; five levels of were used , and the gray values in the image are between 0 and 88. To compare the performances of the two filters, we compute five measurements that appear more frequently in the literature: signal to noise ratio (SNR), peak signal to noise ratio (PSNR), root mean square error (RMSE), mean absolute error (MAE), and the structural similarity index (SSIM). Given two gray level images, a reference image and noise image , of size , the quantities PSNR, RMSE, and MAE are given by

The structural similarity index in a region is estimated as where and are the means over of and , respectively, and are the corresponding variances, is the covariance of and , and the constants and are given by and ; see [27]. If the images are divided in regions, , the SSIM for the two images and is defined by

The resultant SSIM index is a value between −1 and 1, and value 1 is only reachable in the case of two identical data sets. Quantities SNR, PSNR, RMSE, and MAE are currently used in computer and medical sciences to compare two images; however, a good quantitative performance could be not consistent, in some cases, with visual perception. SSIM has become a more convenient way to compare two images, when PSNR and RMSE show indistinguishable results for the perception of the human eye.

Tables 1, 2, 3, 4, and 5 show the errors between the noisy images and the filtered images using the quantities SNR, PSNR, RMSE, MAE and SSIM, respectively. The first row in each table corresponds to the noisy image and various values, the second row corresponds to the filtered image using Kazubek's filter, and the third row corresponds to the filtered image using the modified filter. For each level, our modified Kazubek's algorithm shows an improved performance with respect to the original algorithm using all the criteria to measure the error. The performance of both filters is nearly indistinguishable in the cases and we get better filtered images as the noise level increases to , 8, and 12, see Figure 3.

#### 6. Numerical Results

To see the effect introduced by the filter on a real magnetic resonance image, as a part of a tissue segmentation process, we consider the set of images referenced in [3]. In this case, we have a set of eight echoes (magnetic resonance images of the same axial section) from a sequence of T2-MRI, with an echo time of 44 milliseconds. According to [2, 3] we can see a part of the brain affected by tumoral tissues (ROI1) and another region showing no visible impairment (ROI2); regions ROI1 and ROI2 are called the region of lesion and region of control, respectively. Figure 4 shows the echo corresponding to , from the set of images. For each pixel in a region the variant of Prony method is applied, to find the linear and nonlinear parameters defined in (1) with and ; this process is performed for , and , and we choose the ones minimizing the residual. In Table 6, we show the computation times of the classification process, using our implementation of the variant of the Prony method.

For each region of interest, the frequency diagram is computed as follows: we divided the interval into bins of equal length; , , since the brain tissues relaxation rates belong to this interval, as we can see in [2]. For the pixels in a specific region and a selected subinterval , we add the linear parameters whose corresponding nonlinear parameters belong to , and this process is done for , to get a diagram of frequencies. Each frequency diagram is normalized to obtain a probability density function.

In Figure 5(a), we see the solution obtained in [3], which was calculated by the variant of the Prony method. Figure 5(b) shows the results using our implementation of the variant of the Prony method, in red the probability density corresponding to the control region, and in blue the corresponding to the region of lesion. The differences in the shape of these graphics are caused because our implementation of the method is not the same as that reported in [3]. Figure 5(c) shows the result of applying the MRI filter designed in this paper, on each one of the eight images, before running the variant of the Prony method. The filtering process produces a curve with less dispersion for the region ROI2 and a softer edge in the curve corresponding to region ROI1.

#### 7. Conclusion

This paper takes as its starting point the wavelet domain filter for MRI developed by Kazubek. We improved the original filter introducing the bilateral filter in the wavelet domain. The resulting filter exhibits a better performance and requires only a small increase in computational time of the whole tissue classification process. The new filter is applied to real brain MRI in a process of brain tissue classification proposed by Paluszny et al. [3], getting different results to those previously reported, which lead to an improvement in tissue identification with relaxation techniques. Our results are validated with the main quality criteria for image denoising.

#### Appendix

The power series expansions of functions , and are

Therefore,

* *

#### Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.

#### Acknowledgments

The authors would like to express their acknowledgment to the referees for their comments and suggestion and the support by Universidad Nacional de Colombia through the Project* Fortalecimiento del grupo de Computación Científica*, Hermes code 16084.

#### References

- M. Komiyama, H. Yagura, and M. Baba, “MR imaging: possibility of tissue characterization of brain tumors using ${T}_{1}$ and ${T}_{2}$ values,”
*American Journal of Neuroradiology*, vol. 8, no. 1, pp. 65–70, 1987. View at Google Scholar · View at Scopus - M. Martín-Landrove, F. Mayobre, I. Bautista, and R. Villalta, “Brain tumor evaluation and segmentation by in vivo proton spectroscopy and relaxometry,”
*Magnetic Resonance Materials in Physics, Biology and Medicine*, vol. 18, no. 6, pp. 316–331, 2005. View at Publisher · View at Google Scholar · View at Scopus - M. Paluszny, M. Martín-Landrove, G. Figueroa, and W. Torres, “Boosting the inverse interpolation problem by a sum of decaying exponentials using an algebraic approach,”
*Electronic Transactions on Numerical Analysis*, vol. 34, pp. 163–169, 2008. View at Google Scholar · View at Scopus - M. Martín-Landrove, G. Figueroa, M. Paluszny, and W. Torres, “A quasi-analytical method for relaxation rate distribution determination of ${T}_{2}$-weighted MRI in brain,” in
*Proceedings of the 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society (EMBC '07)*, pp. 1318–1321, Lyon, France, August 2007. View at Publisher · View at Google Scholar · View at Scopus - M. Paluszny, M. Lentini, M. Martin-Landrove, W. Torres, and R. Martin, “Recovery of relaxation rates in MRI ${T}_{2}$-weighted brain images via exponential fitting,” in
*Exponential Data Fitting and Its Applications*, V. Pereyra and G. Scherer, Eds., pp. 52–70, Bentham Science, 2010. View at Google Scholar - R. Jaramillo and M. Lentini, “Stability analysis of a variant of the prony method,”
*Mathematical Problems in Engineering*, vol. 2012, Article ID 390645, 21 pages, 2012. View at Publisher · View at Google Scholar - G. Golub and V. Pereyra, “The differentiation of pseudo-inverses and the nonlinear least squares problem whose variables separate,”
*SIAM Journal on Numerical Analysis*, vol. 10, no. 2, pp. 413–432, 1973. View at Google Scholar - G. Golub and V. Pereyra, “Separable nonlinear least squares: the variable projection method and its applications,”
*Inverse Problems*, vol. 19, no. 2, pp. R1–R26, 2003. View at Publisher · View at Google Scholar · View at Scopus - O. P. O'Leary and B. W. Rust, “Variable projection for nonlinear least squares problems,”
*Computational Optimization and Applications*, vol. 54, no. 3, pp. 579–593, 2013. View at Publisher · View at Google Scholar - M. R. Osborne, “Some special nonlinear least squares problems,”
*SIAM Journal on Numerical Analysis*, vol. 12, no. 4, pp. 571–592, 1975. View at Google Scholar · View at Scopus - M. R. Osborne and G. K. Smyth, “A modify Prony algorithm for fitting functions defined by difference equations,”
*SIAM Journal on Scientific and Statistical Computing*, vol. 12, no. 2, pp. 362–382, 1991. View at Google Scholar - M. R. Osborne and G. K. Smyth, “A modify Prony algorithm for exponential function fitting,”
*SIAM Journal on Scientific and Statistical Computing*, vol. 16, pp. 119–138, 1995. View at Google Scholar - V. Pereyra and G. Scherer, “Exponential data fitting,” in
*Exponential Data Fitting and Its Applications*, V. Pereyra and G. Scherer, Eds., pp. 1–26, Bentham Science, 2010. View at Google Scholar - M. Kazubek, “Bias and noise removal from magnetic MR images,” in
*Proceedings of the International Conference on Computer and Vision graphics (ICCVG '04)*, pp. 929–934, Warsaw, Poland, 2004. - R. D. Nowak, “Wavelet-based Rician noise removal for magnetic resonance imaging,”
*IEEE Transactions on Image Processing*, vol. 8, no. 10, pp. 1408–1419, 1999. View at Publisher · View at Google Scholar · View at Scopus - Q. Pan, L. Zhang, G. Dai, and H. Zhang, “Two denoising methods by wavelet transform,”
*IEEE Transactions on Signal Processing*, vol. 47, no. 12, pp. 3401–3406, 1999. View at Publisher · View at Google Scholar · View at Scopus - L. Jiang and W. Yang, “Adaptive magnetic resonance image denoising using mixture model
and wavelet shrinkage,” in
*Proceedings of the 7th digital imaging computing: Techniques and applications*, C. Sun, H. Talbot, S. Ourselin, and T. Adriaansen, Eds., pp. 831–838, Sydney, Australia, 2003. - E. T. H. Leung and J. K. Tsotsos, “Adaptive enhancement of cardiac magnetic resonance
(CMR) images,” in
*Proceedings of the tenth International Conference in Computer Vision, (ICCV '05)*, pp. 1739–1746, Beijing, China, 2005. - C. S. Anand and J. S. Sahambi, “MRI denoising using bilateral filter in redundant wavelet domain,” in
*Proceedings of the IEEE Region 10 Conference (TENCON '08)*, Washington, DC, USA, November 2008. View at Publisher · View at Google Scholar · View at Scopus - C. S. Anand and J. S. Sahambi, “Wavelet domain non-linear filtering for MRI denoising,”
*Magnetic Resonance Imaging*, vol. 28, no. 6, pp. 842–861, 2010. View at Publisher · View at Google Scholar · View at Scopus - K. Bartusek, J. Prinosil, and Z. Smekal, “Optimization of wavelet-based de-noising in MRI,”
*Radioengineering*, vol. 20, no. 1, pp. 85–93, 2011. View at Google Scholar · View at Scopus - Z. A. Mustafa and Y. M. Kadah, “Multi resolution bilateral filter for MR image denoising,” in
*Proceedings of the 1st Middle East Conference on Biomedical Engineering (MECBME '11)*, pp. 180–184, Sharjah, United Arab Emirates, February 2011. View at Publisher · View at Google Scholar · View at Scopus - H. Gudbjartsson and S. Patz, “The Rician distribution of noisy MRI data,”
*Magnetic Resonance in Medicine*, vol. 34, no. 6, pp. 910–914, 1995. View at Publisher · View at Google Scholar · View at Scopus - C. Tomasi and R. Manduchi, “Bilateral filtering for gray and color images,” in
*Proceedings of the 1998 IEEE 6th International Conference on Computer Vision*, pp. 839–846, New Delhi, India, January 1998. View at Scopus - M. Abramowitz and I. A. Stegun,
*Handbook of Mathematical Functions*, Dover publications, New York, NY, USA, 1972. - D. F. Walnut,
*An Introduction To Wavelet Analysis*, Birkhäuser, Boston, Mass, USA, 2004. - Z. Wang, A. C. Bovik, H. R. Sheikh, and E. P. Simoncelli, “Image quality assessment: from error visibility to structural similarity,”
*IEEE Transactions on Image Processing*, vol. 13, no. 4, pp. 600–612, 2004. View at Publisher · View at Google Scholar · View at Scopus