Research Article

Modeling the Relationship between Fluorodeoxyglucose Uptake and Tumor Radioresistance as a Function of the Tumor Microenvironment

Table 1

Parameter values for different compartments and the ranges of GF and CLF used in the model simulation.

Compartment

Oxygen enhancement ratio (OER)121.37

Glucose uptake level per cellVaries depending on the hypothetical FDG uptake patterna

Proliferation fraction50–100%b

Cell loss mechanism and rateMitotic cell death due to irradiation (survival rate of each progeny after mitosis: 0.3)Cell loss due to starvation (cell loss half time: 2 days)

Growth fraction (GF) range applied0.01 to 1/(2 + CLF) [0.01 step]

Cell loss factor (CLF) range applied0.03 to 0.99 [0.03 step]

The relative uptake ratios in P : I : H are 1 : 1 : 0, 3 : 1 : 0, 1 : 3 : 0, and 2 : 5 : 2 for patterns I, II, III, and IV, respectively, as shown in Figure 2.
Depends on the fullness of the compartment: 50% of proliferation was assumed when the compartment is full, and 100% of proliferation was assumed when the number of cells is less than half of the capacity of the P-compartment.