Research Article

Dynamic Regulatory Network Reconstruction for Alzheimer’s Disease Based on Matrix Decomposition Techniques

Table 1

Selected TFs and the target genes.

Selected TFsDescriptionChromosome locations and promoter IDTarget genes Number of TGs

ZNF207Zinc finger protein 20717q12,  
promoter ID: 17074
GNB1, CLIP1, SFRS18, CSNK1D, SFPQ, CSNK1A1, ASNS, ZBTB20, TUBB, TM2D1, TIMM17A, ENO1, ASH1L, NONO, KPNA2, REEP5, NSF, HSPD1, UBE2D3, DICER1, and G3BP121

BUB3BUB3 budding uninhibited by benzimidazoles 3 homolog10q26 
promoter ID: 5046
TARDBP, ATP1B1, SFPQ, GNB1, CLIP1, SET, ARPC5L, NCOA1, NOL5A, PPIA, CEP27, REEP5, ENO1, ASNS, ZBTB20, HSPD1, PSMB1, NONO, and KPNA219

PTBP1Polypyrimidine tract binding protein 119p13.3 
promoter ID: 20018
PABPN1, UBL3, REEP5, KIAA0232, SET, G3BP1, ENO1, GTF2I, SMARCA4, ASH1L, WDR1, CSNK1D, HSP90AB1, TUBB, FKBP1A, YWHAZ, HSPD1, VAMP4, and NONO19

ZBTB20Zinc finger and BTB domain containing 203q13.2 
promoter ID: 119577
POGZ, NFIB, CIRBP, TIMM17A, CEP27, SNRPN, ARHGAP5, TUBB, RUFY3, EZH1, NCOA1, GSTA4, KTN1, RPL35A, GPRASP1, PDE4C, SLC35E1, RABGEF1, and ZNF16019

COPACoatomer protein complex, subunit alpha1q23–25 
promoter ID: 2753
G3BP1, TM2D1, GNB1, GTF2I, RIPK5, DCTN4, SCAMP1, HSPA8, RAB6A, CANX, WDR1, ACTB, CSNK1A1, HSP90AB1, and YWHAZ15

E2F4E2F transcription factor 4, p107/p130 binding16q21-q22 
promoter ID: 15321
RUFY3, NTRK2, GABRB2, ENO1, BAIAP2, KTN1, DPP6, PDE4C, EZH1, ITFG1, NECAP1, JAK1, NLRP1, and CHERP14

POLR2EPolymerase (RNA) II (DNA directed) polypeptide E, 25 kDa19p13.3 
promoter ID: 22868
SMARCA4, ASH1L, RIPK5, HSBP1, UBE2D3, GNB1, HSPA8, NONO, GSTO1, PGK1, ENO1, WDR1, FKBP1A, and HSP90AB114

STIP1Stress-induced phosphoprotein 1 11q13 
promoter ID: 6654
SFPQ, HSBP1, GTF2I, FAM108B1, GNB1, G3BP1, RAB6A, WDR1, HSPA8, ENO1, NONO, YWHAZ, HSPD1, and HSP90AB114

ANAPC5Anaphase promoting complex subunit 512q24.31 
promoter ID: 9688
CEP27, FAM108B1, G3BP1, GTF2I, HSBP1, HSP90AB1, HSPA8, NONO, PGK1, PSMA1, RAB6A, RIPK5, and YWHAZ13

RNF38Ring finger protein 389p13-12 
promoter ID: 42818
REEP5, SSX2IP, DCTN4, DCUN1D4, HSPA8, C1orf43, SFPQ, ASH1L, ITFG1, HSP90AB1, YWHAZ, MGEA5, and FOXJ313