First Comprehensive In Silico Analysis of the Functional and Structural Consequences of SNPs in Human GalNAc-T1 Gene
Figure 6
3D visualization of G258V variant with MUC1. (a) Ligand binding of GalNAc-T1 native structure with MUC1 indicated single H-bonding interaction (green line) of Gly258 residue (green portion) with Arg266 which is further connected with the GVTSA (tandem repeat region of MUC1) by means of H-bonding interaction. (b) Picturing of GalNAc-T1 mutant protein structure is observed with one H-bonding loss between Arg266 residue and the MUC1 tandem repeat motif.
