Research Article

BioTCM-SE: A Semantic Search Engine for the Information Retrieval of Modern Biology and Traditional Chinese Medicine

Table 2

Examples of TCM herb-related diseases and bioentities: proteins, genes, and gene products.

Herb Diseases Number Proteins Genes Gene products

Artemisia annua Malaria 58 Hemoglobin subunit alpha, Lymphotoxin-beta COL13A1, MMP9 Apical constriction, apyrase activity, pseudohyphal growth

Artemisia annua Breast neoplasm 9 Sex hormone-binding globulin, Prolactin receptor SHBG, PRLR Protein complex assembly multichaperone pathway

Aconitum carmichaelii Hypertension 179 Mineralocorticoid receptor, endothelial Nitric oxide synthase NR3C2, NOS3 Ethanolamine-phosphate cytidylyltransferase activity, urate oxidase activity

Aconitum carmichaelii Arthritis 13 Endothelial Nitric oxide synthase, Uridine-cytidine kinase 2 NOS3, UCK2 Phospholipid biosynthetic process, ventral midline determination

Ginkgo biloba Alzheimer’s disease 161 Urokinase-type plasminogen activator, Tumor necrosis factor PLAU, TNF Neurotransmitter: sodium symporter activity, pseudohyphal growth

Ginkgo biloba Atherosclerosis 24 Prostaglandin G/H synthase 1, Cytosolic phospholipase A2 VEGFA, PLA2G4A Peripheral nervous system development, high-density lipoprotein

Salvia miltiorrhiza Asthma 92 Phenylalanine-4-hydroxylase, Vascular endothelial growth factor A PAH, VEGFA Protein kinase C activity, type II intermediate filament associated protein

Salvia miltiorrhiza Parkinson’s Disease 104 Mitochondrial Glutamate dehydrogenase 1, Estrogen receptor GLUD1, ESR1 Antigen processing and presentation following pinocytosis, tRNA wobble guanine modification