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Computational and Mathematical Methods in Medicine
Volume 2014, Article ID 985789, 14 pages
Research Article

An Efficient Diagnosis System for Parkinson’s Disease Using Kernel-Based Extreme Learning Machine with Subtractive Clustering Features Weighting Approach

1College of Computer Science and Technology, Jilin University, No. 2699, QianJin Road, Changchun 130012, China
2Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun 130012, China
3College of Physics and Electronic Information, Wenzhou University, Wenzhou 325035, China

Received 21 June 2014; Accepted 26 October 2014; Published 18 November 2014

Academic Editor: Dong Song

Copyright © 2014 Chao Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A novel hybrid method named SCFW-KELM, which integrates effective subtractive clustering features weighting and a fast classifier kernel-based extreme learning machine (KELM), has been introduced for the diagnosis of PD. In the proposed method, SCFW is used as a data preprocessing tool, which aims at decreasing the variance in features of the PD dataset, in order to further improve the diagnostic accuracy of the KELM classifier. The impact of the type of kernel functions on the performance of KELM has been investigated in detail. The efficiency and effectiveness of the proposed method have been rigorously evaluated against the PD dataset in terms of classification accuracy, sensitivity, specificity, area under the receiver operating characteristic (ROC) curve (AUC), f-measure, and kappa statistics value. Experimental results have demonstrated that the proposed SCFW-KELM significantly outperforms SVM-based, KNN-based, and ELM-based approaches and other methods in the literature and achieved highest classification results reported so far via 10-fold cross validation scheme, with the classification accuracy of 99.49%, the sensitivity of 100%, the specificity of 99.39%, AUC of 99.69%, the f-measure value of 0.9964, and kappa value of 0.9867. Promisingly, the proposed method might serve as a new candidate of powerful methods for the diagnosis of PD with excellent performance.