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Computational and Mathematical Methods in Medicine
Volume 2015, Article ID 103843, 10 pages
Research Article

Multimodality Functional Imaging in Radiation Therapy Planning: Relationships between Dynamic Contrast-Enhanced MRI, Diffusion-Weighted MRI, and 18F-FDG PET

1Medical Physics Department and Radiological Protection, Galaria-Hospital do Meixoeiro-Complexo Hospitalario Universitario de Vigo, 36200 Vigo, Spain
2Signal Theory and Communications Department, University of Vigo, 36310 Vigo, Spain
3Radiation Medicine Program, Princess Margaret Cancer Centre and University Health Network, Toronto, ON, Canada M5T 2M9
4Radiation Oncology Department, Galaria-Hospital do Meixoeiro-Complexo Hospitalario Universitario de Vigo, 36200 Vigo, Spain

Received 4 July 2014; Revised 15 September 2014; Accepted 10 October 2014

Academic Editor: Alexandru Dasu

Copyright © 2015 Moisés Mera Iglesias et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. Biologically guided radiotherapy needs an understanding of how different functional imaging techniques interact and link together. We analyse three functional imaging techniques that can be useful tools for achieving this objective. Materials and Methods. The three different imaging modalities from one selected patient are ADC maps, DCE-MRI, and 18F-FDG PET/CT, because they are widely used and give a great amount of complementary information. We show the relationship between these three datasets and evaluate them as markers for tumour response or hypoxia marker. Thus, vascularization measured using DCE-MRI parameters can determine tumour hypoxia, and ADC maps can be used for evaluating tumour response. Results. ADC and DCE-MRI include information from 18F-FDG, as glucose metabolism is associated with hypoxia and tumour cell density, although 18F-FDG includes more information about the malignancy of the tumour. The main disadvantage of ADC maps is the distortion, and we used only low distorted regions, and extracellular volume calculated from DCE-MRI can be considered equivalent to ADC in well-vascularized areas. Conclusion. A dataset for achieving the biologically guided radiotherapy must include a tumour density study and a hypoxia marker. This information can be achieved using only MRI data or only PET/CT studies or mixing both datasets.