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Computational and Mathematical Methods in Medicine
Volume 2015, Article ID 124325, 8 pages
Research Article

Windowed Multitaper Correlation Analysis of Multimodal Brain Monitoring Parameters

Department of Neurosurgery, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93042 Regensburg, Germany

Received 15 September 2014; Accepted 16 February 2015

Academic Editor: Michel Dojat

Copyright © 2015 Rupert Faltermeier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although multimodal monitoring sets the standard in daily practice of neurocritical care, problem-oriented analysis tools to interpret the huge amount of data are lacking. Recently a mathematical model was presented that simulates the cerebral perfusion and oxygen supply in case of a severe head trauma, predicting the appearance of distinct correlations between arterial blood pressure and intracranial pressure. In this study we present a set of mathematical tools that reliably detect the predicted correlations in data recorded at a neurocritical care unit. The time resolved correlations will be identified by a windowing technique combined with Fourier-based coherence calculations. The phasing of the data is detected by means of Hilbert phase difference within the above mentioned windows. A statistical testing method is introduced that allows tuning the parameters of the windowing method in such a way that a predefined accuracy is reached. With this method the data of fifteen patients were examined in which we found the predicted correlation in each patient. Additionally it could be shown that the occurrence of a distinct correlation parameter, called scp, represents a predictive value of high quality for the patients outcome.