Monte Carlo Calculation of Radioimmunotherapy with ⁹⁰Y-, ¹⁷⁷Lu-, ¹³¹I-, ¹²⁴I-, and ¹⁸⁸Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts

Table 5

Total absorbed dose (), absorbed doses at the surface (), and absorbed doses at the centre () or surrounding the tumour (), in Gy, required to obtain a maximum TCP of 100% when nanoobjects containing ⁹⁰Y, ¹³¹I, ¹²⁴I, ¹⁷⁷Lu, and ¹⁸⁸Re are coupled to antibodies having a of 6 days and distributed uniformly, linearly, and exponentially inside a 0.5 cm radius spherical tumour. : number of radioactive atoms per nanoobjects required for TCP = 100%.

Rad.	Dist.	[kBq]			Dose
			Direct uptake	2 days of uptake	[Gy]	[Gy]	[Gy]	[Gy]
^90Y	Uni.	370	2	4	77	108	52	10
	Lin.	370	2	4	69	70	52	10
	Exp.	370	3	5	79	48	79	12
^131I	Uni.	370	15	18	88	104	54	10
	Lin.	370	17	20	95	59	68	11
	Exp.	1850	61	72	336	55	409	39
^124I	Uni.	370	9	13	74	100	53	13
	Lin.	370	8	12	67	64	53	12
	Exp.	740	15	21	112	56	113	22
^177Lu	Uni.	740	21	26	95	114	54	8
	Lin.	740	26	33	117	64	82	10
	Exp.	6660	188	232	820	63	1046	72
^188Re	Uni.	740	2	15	72	101	48	11
	Lin.	740	2	14	64	62	48	10
	Exp.	1110	3	21	90	46	92	15