Genetic Consequences of Antiviral Therapy on HIV-1

Figure 2

Sequence difference variation as a function of time interval between samples. (a) Variation of the overall sequence difference between the two datasets of each evolutionary scenario ( − ) is represented in the “-axis” (mean and standard error). The time period between both samples ( − ) is represented in the “-axis” (mean and standard error from all patients of the scenario). The correlation coefficient between both parameters among all the scenarios is , suggesting absence of correlation. Correlation coefficients within each evolutionary scenario (among patients) between these parameters are also shown in the plot and ranges from 0.0003 to 0.507, although most of them are under 0.1. (b) Genetic diversity gradient divided by the corresponding time period. Error bars indicate standard error. “−” indicates naïve-treatment patients. Reference values are shown in Table S1 (Supplementary Material).

(a)

(b)