Computational and Mathematical Methods in Medicine / 2015 / Article / Tab 2

Research Article

Identifying New Candidate Genes and Chemicals Related to Prostate Cancer Using a Hybrid Network and Shortest Path Approach

Table 2

The top ten GO terms shared by 187 significant candidate genes.

GO term IDGO termGenes sharing the GO termFDR

GO:0042127Regulation of cell proliferationFGFR2, FGFR1, CCL2, PDGFB, NDN, MITF, STRN, GNRHR, VIPR1, FOXO4, GHRHR, TGFB1, CTNNB1, GLI1, MAGED1, CTTNBP2, VDR, CASP3, MYOCD, SFTPD, SHC1, MUC2, PTGER2, GNRH1, CDK6, LIG4, DBH, NTN1, CDKN1C, PRKCQ, CCND1, HNF4A, HGS, TGFBR3, PDGFRB, PTCH1, SST, ADRA1D, and LRP5

GO:0010033Response to organic substanceCGA, CCL2, PDGFB, LHCGR, NR3C1, FOXO4, TGFB1, GHRHR, CTNNB1, B2M, CTTNBP2, TNFRSF1A, CASP3, REN, RARA, SHC1, KCNMA1, GNRH1, CSNK2B, ESR1, DBH, BIRC2, PRKCQ, CCND1, HNF4A, MAPK14, ALDH2, HSD11B2, HSPB1, TGFBR3, PTCH1, IRF3, SST, and CD14

GO:0042981Regulation of apoptosisTRAF2, C9, CCL2, MITF, PPP3R1, NFKB1, RRM2B, NR3C1, TGFB1, MAGED1, MAP3K7, VDR, BAK1, MAP3K5, CASP3, NQO1, TERT, MAP2K6, RASA1, TERF1, KCNMA1, MUC2, GNRH1, ROCK1, ESR1, LIG4, DBH, BIRC2, TNFRSF10B, NTRK1, UBC, HSPB1, IKBKB, SST, and GSTP1

GO:0043067Regulation of programmed cell deathTRAF2, C9, CCL2, MITF, PPP3R1, NFKB1, RRM2B, NR3C1, TGFB1, MAGED1, MAP3K7, VDR, BAK1, MAP3K5, CASP3, NQO1, TERT, MAP2K6, RASA1, TERF1, KCNMA1, MUC2, GNRH1, ROCK1, ESR1, LIG4, DBH, BIRC2, TNFRSF10B, NTRK1, UBC, HSPB1, IKBKB, SST, and GSTP1

GO:0010941Regulation of cell deathTRAF2, C9, CCL2, MITF, PPP3R1, NFKB1, RRM2B, NR3C1, TGFB1, MAGED1, MAP3K7, VDR, BAK1, MAP3K5, CASP3, NQO1, TERT, MAP2K6, RASA1, TERF1, KCNMA1, MUC2, GNRH1, ROCK1, ESR1, LIG4, DBH, BIRC2, TNFRSF10B, NTRK1, UBC, HSPB1, IKBKB, SST, and GSTP1

GO:0009719Response to endogenous stimulusKCNMA1, CGA, CCL2, GNRH1, PDGFB, LHCGR, ESR1, FOXO4, DBH, BIRC2, TGFB1, GHRHR, CTNNB1, CTTNBP2, PRKCQ, CCND1, REN, ALDH2, TGFBR3, HSD11B2, RARA, SHC1, PTCH1, and SST

GO:0016477Cell migrationICAM1, CCL2, ROCK1, PDGFB, NDN, NUP85, CDH2, CX3CL1, DBH, NTN1, TGFB1, CTTNBP2, WNT1, CKLF, LRP6, SFTPD, TGFBR3, PDGFRB, SCNN1B, and LRP5

GO:0007242Intracellular signaling cascadeTRAF2, FGFR1, CYP24A1, CCL2, LHCGR, NR3C1, VIPR1, FOXO4, GHRHR, CTNNB1, MAP3K7, VDR, MAP3K5, MAP3K3, REN, RARA, SHC1, RASA1, MAP2K6, CNKSR1, CCM2, ROCK1, ESR1, RALGDS, FLNA, PRKCQ, CCND1, NCOA1, TNFRSF10B, PLCG1, NEDD4, MAPK14, NTRK1, KRIT1, GADD45G, MAPK3, RAB5A, TGFBR3, IRF3, IKBKB, ADRA1D, GRB14, DUSP6

GO:0009725Response to hormone stimulusKCNMA1, CGA, CCL2, GNRH1, PDGFB, LHCGR, ESR1, FOXO4, GHRHR, TGFB1, CTNNB1, CTTNBP2, PRKCQ, CCND1, REN, ALDH2, TGFBR3, HSD11B2, RARA, SHC1, PTCH1, SST

GO:0048870Cell motilityICAM1, CCL2, ROCK1, PDGFB, NDN, NUP85, CDH2, CX3CL1, DBH, NTN1, TGFB1, CTTNBP2, WNT1, CKLF, LRP6, SFTPD, TGFBR3, PDGFRB, SCNN1B, LRP5

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