Identifying New Candidate Genes and Chemicals Related to Prostate Cancer Using a Hybrid Network and Shortest Path Approach

Table 2

The top ten GO terms shared by 187 significant candidate genes.

GO term ID	GO term	Genes sharing the GO term	FDR
GO:0042127	Regulation of cell proliferation	FGFR2, FGFR1, CCL2, PDGFB, NDN, MITF, STRN, GNRHR, VIPR1, FOXO4, GHRHR, TGFB1, CTNNB1, GLI1, MAGED1, CTTNBP2, VDR, CASP3, MYOCD, SFTPD, SHC1, MUC2, PTGER2, GNRH1, CDK6, LIG4, DBH, NTN1, CDKN1C, PRKCQ, CCND1, HNF4A, HGS, TGFBR3, PDGFRB, PTCH1, SST, ADRA1D, and LRP5
GO:0010033	Response to organic substance	CGA, CCL2, PDGFB, LHCGR, NR3C1, FOXO4, TGFB1, GHRHR, CTNNB1, B2M, CTTNBP2, TNFRSF1A, CASP3, REN, RARA, SHC1, KCNMA1, GNRH1, CSNK2B, ESR1, DBH, BIRC2, PRKCQ, CCND1, HNF4A, MAPK14, ALDH2, HSD11B2, HSPB1, TGFBR3, PTCH1, IRF3, SST, and CD14
GO:0042981	Regulation of apoptosis	TRAF2, C9, CCL2, MITF, PPP3R1, NFKB1, RRM2B, NR3C1, TGFB1, MAGED1, MAP3K7, VDR, BAK1, MAP3K5, CASP3, NQO1, TERT, MAP2K6, RASA1, TERF1, KCNMA1, MUC2, GNRH1, ROCK1, ESR1, LIG4, DBH, BIRC2, TNFRSF10B, NTRK1, UBC, HSPB1, IKBKB, SST, and GSTP1
GO:0043067	Regulation of programmed cell death	TRAF2, C9, CCL2, MITF, PPP3R1, NFKB1, RRM2B, NR3C1, TGFB1, MAGED1, MAP3K7, VDR, BAK1, MAP3K5, CASP3, NQO1, TERT, MAP2K6, RASA1, TERF1, KCNMA1, MUC2, GNRH1, ROCK1, ESR1, LIG4, DBH, BIRC2, TNFRSF10B, NTRK1, UBC, HSPB1, IKBKB, SST, and GSTP1
GO:0010941	Regulation of cell death	TRAF2, C9, CCL2, MITF, PPP3R1, NFKB1, RRM2B, NR3C1, TGFB1, MAGED1, MAP3K7, VDR, BAK1, MAP3K5, CASP3, NQO1, TERT, MAP2K6, RASA1, TERF1, KCNMA1, MUC2, GNRH1, ROCK1, ESR1, LIG4, DBH, BIRC2, TNFRSF10B, NTRK1, UBC, HSPB1, IKBKB, SST, and GSTP1
GO:0009719	Response to endogenous stimulus	KCNMA1, CGA, CCL2, GNRH1, PDGFB, LHCGR, ESR1, FOXO4, DBH, BIRC2, TGFB1, GHRHR, CTNNB1, CTTNBP2, PRKCQ, CCND1, REN, ALDH2, TGFBR3, HSD11B2, RARA, SHC1, PTCH1, and SST
GO:0016477	Cell migration	ICAM1, CCL2, ROCK1, PDGFB, NDN, NUP85, CDH2, CX3CL1, DBH, NTN1, TGFB1, CTTNBP2, WNT1, CKLF, LRP6, SFTPD, TGFBR3, PDGFRB, SCNN1B, and LRP5
GO:0007242	Intracellular signaling cascade	TRAF2, FGFR1, CYP24A1, CCL2, LHCGR, NR3C1, VIPR1, FOXO4, GHRHR, CTNNB1, MAP3K7, VDR, MAP3K5, MAP3K3, REN, RARA, SHC1, RASA1, MAP2K6, CNKSR1, CCM2, ROCK1, ESR1, RALGDS, FLNA, PRKCQ, CCND1, NCOA1, TNFRSF10B, PLCG1, NEDD4, MAPK14, NTRK1, KRIT1, GADD45G, MAPK3, RAB5A, TGFBR3, IRF3, IKBKB, ADRA1D, GRB14, DUSP6
GO:0009725	Response to hormone stimulus	KCNMA1, CGA, CCL2, GNRH1, PDGFB, LHCGR, ESR1, FOXO4, GHRHR, TGFB1, CTNNB1, CTTNBP2, PRKCQ, CCND1, REN, ALDH2, TGFBR3, HSD11B2, RARA, SHC1, PTCH1, SST
GO:0048870	Cell motility	ICAM1, CCL2, ROCK1, PDGFB, NDN, NUP85, CDH2, CX3CL1, DBH, NTN1, TGFB1, CTTNBP2, WNT1, CKLF, LRP6, SFTPD, TGFBR3, PDGFRB, SCNN1B, LRP5