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Computational and Mathematical Methods in Medicine
Volume 2015, Article ID 479014, 9 pages
Review Article

Perspectives in Intraoperative Diagnostics of Human Gliomas

1Lobachevsky State University of Nizhni Novgorod, Institute of Biology and Biomedicine, Russia
2Federal State Budgetary Institution, “Privolzhsky Federal Research Medical Centre” of the Ministry of Health of the Russian Federation, Russia
3Nizhny Novgorod State Medical Academy, Russia

Received 7 June 2015; Accepted 25 June 2015

Academic Editor: Alexey Zaikin

Copyright © 2015 O. Tyurikova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Amongst large a variety of oncological diseases, malignant gliomas represent one of the most severe types of tumors. They are also the most common type of the brain tumors and account for over half of the astrocytic tumors. According to different sources, the average life expectancy of patients with various glioblastomas varies between 10 and 12 months and that of patients with anaplastic astrocytic tumors between 20 and 24 months. Therefore, studies of the physiology of transformed glial cells are critical for the development of treatment methods. Modern medical approaches offer complex procedures, including the microsurgical tumor removal, radiotherapy, and chemotherapy, supplemented with photodynamic therapy and immunotherapy. The most radical of them is surgical resection, which allows removing the largest part of the tumor, reduces the intracranial hypertension, and minimizes the degree of neurological deficit. However, complete removal of the tumor remains impossible. The main limitations are insufficient visualization of glioma boundaries, due to its infiltrative growth, and the necessity to preserve healthy tissue. This review is devoted to the description of advantages and disadvantages of modern intraoperative diagnostics of human gliomas and highlights potential perspectives for development of their treatment.