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Computational and Mathematical Methods in Medicine
Volume 2015, Article ID 485495, 12 pages
Research Article

Segmentation of Brain Tissues from Magnetic Resonance Images Using Adaptively Regularized Kernel-Based Fuzzy -Means Clustering

1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Boulevard, Shenzhen 518055, China
2University of Chinese Academy of Sciences, 52 Sanlihe Road, Beijing 100864, China
3Faculty of Computers and Information, Mansoura University, Elgomhouria Street, Mansoura 35516, Egypt

Received 29 September 2015; Accepted 23 November 2015

Academic Editor: Jesús Picó

Copyright © 2015 Ahmed Elazab et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An adaptively regularized kernel-based fuzzy -means clustering framework is proposed for segmentation of brain magnetic resonance images. The framework can be in the form of three algorithms for the local average grayscale being replaced by the grayscale of the average filter, median filter, and devised weighted images, respectively. The algorithms employ the heterogeneity of grayscales in the neighborhood and exploit this measure for local contextual information and replace the standard Euclidean distance with Gaussian radial basis kernel functions. The main advantages are adaptiveness to local context, enhanced robustness to preserve image details, independence of clustering parameters, and decreased computational costs. The algorithms have been validated against both synthetic and clinical magnetic resonance images with different types and levels of noises and compared with 6 recent soft clustering algorithms. Experimental results show that the proposed algorithms are superior in preserving image details and segmentation accuracy while maintaining a low computational complexity.