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Computational and Mathematical Methods in Medicine
Volume 2015, Article ID 612580, 7 pages
http://dx.doi.org/10.1155/2015/612580
Research Article

Autoradiography Imaging in Targeted Alpha Therapy with Timepix Detector

1Department of Medical Physics, Royal Adelaide Hospital, Adelaide, Australia
2School of Chemistry and Physics, University of Adelaide, Adelaide, Australia
3Translational Oncology Laboratory, Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, Australia
4School of Medicine, University of Adelaide, Australia
5Cancer Clinical Trials Unit, Royal Adelaide Hospital, Adelaide, Australia

Received 25 July 2014; Accepted 14 October 2014

Academic Editor: Loredana G. Marcu

Copyright © 2015 Ruqaya AL Darwish et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Mayles, A. Nahum, and J. C. Rosenwald, Handbook of Radiotherapy Physics: Theory and Practice, Taylor & Francis, New York, NY, USA, 2007.
  2. L. Marcu, E. Bezak, and B. J. Allen, Biomedical Physics in Radiotherapy for Cancer, CSIRO, Collingwood, Australia, 2012.
  3. C.-Y. Huang, S. Guatelli, B. M. Oborn, and B. J. Allen, “Microdosimetry for targeted alpha therapy of cancer,” Computational and Mathematical Methods in Medicine, vol. 2012, Article ID 153212, 6 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. A. H. Staudacher, E. Bezak, A. Borysenko, and M. P. Brown, “Targeted α-therapy using 227Th-APOMAB and cross-fire antitumour effects: preliminary in-vivo evaluation,” Nuclear Medicine Communications, vol. 35, no. 12, pp. 1284–1290, 2014. View at Publisher · View at Google Scholar
  5. V. Kraus, M. Holik, J. Jakubek, M. Kroupa, P. Soukup, and Z. Vykydal, “FITPix—fast interface for Timepix pixel detectors,” Journal of Instrumentation, vol. 6, no. 1, Article ID C01079, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Bäck and L. Jacobsson, “The α-camera: a quantitative digital autoradiography technique using a charge-coupled device for ex vivo high-resolution bioimaging of α-particles,” The Journal of Nuclear Medicine, vol. 51, no. 10, pp. 1616–1623, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Chouin, S. Lindegren, S. H. L. Frost et al., “Ex vivo activity quantification in micrometastases at the cellular scale using the α-camera technique,” Journal of Nuclear Medicine, vol. 54, no. 8, pp. 1347–1353, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. T. K. Rügheimer, U. Gebert, T. Michel, G. Anton, J. Séguinot, and C. Joram, “Experimental demonstration of a hybrid photon detector concept based on the Timepix detector,” Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 595, no. 2, pp. 353–358, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. CERN, Medipix, 2011, http://medipix.web.cern.ch/medipix/.
  10. X. Llopart, R. Ballabriga, M. Campbell, L. Tlustos, and W. Wong, “Timepix, a 65k programmable pixel readout chip for arrival time, energy and/or photon counting measurements,” Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 581, no. 1-2, pp. 485–494, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Campbell, V. Havranek, E. Heijne et al., “Charge collection from proton and alpha particle tracks in silicon pixel detector devices,” in Proceedings of the IEEE Nuclear Science Symposium Conference Record (NSS '07), vol. 2, pp. 1047–1050, Honolulu, Hawaii, USA, October-November 2007. View at Publisher · View at Google Scholar
  12. M. Esposito, J. Jakubek, G. Mettivier, S. Pospisil, P. Russo, and J. Solc, “Energy sensitive Timepix silicon detector for electron imaging,” Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 652, no. 1, pp. 458–461, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Esposito, G. Mettivier, and P. Russo, “14C autoradiography with an energy-sensitive silicon pixel detector,” Physics in Medicine and Biology, vol. 56, no. 7, pp. 1947–1965, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Al-Ejeh, J. M. Darby, C. Tsopelas, D. Smyth, J. Manavis, and M. P. Brown, “APOMAB, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy,” PLoS ONE, vol. 4, no. 2, Article ID e4558, 2009. View at Publisher · View at Google Scholar
  15. F. Al-Ejeh, J. M. Darby, and M. P. Brown, “Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors,” PLoS ONE, vol. 4, no. 2, Article ID e4630, 2009. View at Google Scholar
  16. A. H. Staudacher, F. Al-Ejeh, C. K. Fraser et al., “The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the la-specific antibody APOMAB,” EJNMMI Research, vol. 4, no. 1, pp. 1–13, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. IAEA, “Alpha emitting radionuclides and radiopharmaceuticals for therapy,” Tech. Rep. TM-44815, IAEA, Wien, Austria, 2013. View at Google Scholar
  18. R. H. Larsen, J. Borrebaek, J. Dahle et al., “Preparation of TH227-labeled radioimmunoconjugates, assessment of serum stability and antigen binding ability,” Cancer Biotherapy and Radiopharmaceuticals, vol. 22, no. 3, pp. 431–437, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. Advancing Nuclear Medicine Through Innovation, National Academies Press, Washington, DC, USA, 2007.
  20. F. Al-Ejeh, J. M. Darby, and M. P. Brown, “The La autoantigen is a malignancy-associated cell death target that is induced by DNA-damaging drugs,” Clinical Cancer Research, vol. 13, no. 18, part 2, pp. 5509s–5518s, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Al-Ejeh, J. M. Darby, B. Thierry, and M. P. Brown, “A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution,” Nuclear Medicine and Biology, vol. 36, no. 4, pp. 395–402, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Cherry, J. Sorenson, and M. Phelps, Physics in Nuclear Medicine, Elsevier Health Sciences, London, UK, 2012.