Evolutionary Influenced Interaction Pattern as Indicator for the Investigation of Natural Variants Causing Nephrogenic Diabetes Insipidus

Figure 3

Structural colouring of helical ranges with high similarity to aquaporins (PF00230). Side and top-down view of the aquaporin-2 representative protein (PDB-Id: 4oj2). Green coloured cartoon residue ranges are present. These consist of family specific EIPPs which were found in known structures of the given family (PF00230). Red coloured spheres illustrate natural variants derived from UniProt (http://www.uniprot.org/uniprot/P41181) of the protein sequence caused by nephrogenic diabetes insipidus. All figures were rendered with PyMOL.