Computational and Mathematical Methods in Medicine / 2015 / Article / Tab 2

Research Article

Unified Modeling of Familial Mediterranean Fever and Cryopyrin Associated Periodic Syndromes

Table 2

The parameters used in the model.

Explanation

Maximum rate of I and A binding to the receptor
Strength of positive feedback
Strength of negative feedback
Maximum rate to form Cryopyrin inflammasome
Maximum rate of PC production

Threshold for I to induce R
Threshold for A to suppress R
Threshold for R to induce I
Threshold for R to induce A
Threshold for PC to induce C
Threshold for T to induce C
Threshold for P to suppress C
Threshold for P to suppress PC

Degradation rate of R
Degradation rate of I
Degradation rate of A
Degradation rate of C
Degradation rate of PC

Basal synthesis rate of R
Basal synthesis rate of A
Basal synthesis rate of C
Basal synthesis rate of PC

Conversion rate of PC into C
Hill function cooperativity exponent
Proportionality constant of C and I