The Structural Characterization of Tumor Fusion Genes and Proteins

Figure 5

The structure characterization of EML4-ALK variant 1 fusion protein. (a) Disorder tendency of EML4-ALK variant 1 sequence predicted by IUPred. (b) The crystal structure of EML4 homology EML1, PDB id 4CI8. The subunits that form EML4-ALK variant 1 fusion protein are shown in cartoon, and the rest of the parts are shown in surface. (c) The crystal structure of the kinase domain of ALK protein that constitutes the C-terminal side of the EML4-ALK fusion protein. (d) The modeled EML4-ALK variant 1 protein by the structure of EML4 and ALK. A loop was added to connect the two parts.